Academic Journal
Multifacility Outbreak of NDM/OXA-23–Producing Acinetobacter baumannii in California, 2020–2021
| العنوان: | Multifacility Outbreak of NDM/OXA-23–Producing Acinetobacter baumannii in California, 2020–2021 |
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| المؤلفون: | Holden, Diana, Mitsunaga, Tisha, Sanford, Denise, Fryer, Tanya, Nash, June, Schneider, Emily, Mukhopadhyay, Rituparna, Epson, Erin, Sylvester, Matthew |
| المصدر: | Antimicrobial Stewardship & Healthcare Epidemiology ; volume 1, issue S1, page s79-s79 ; ISSN 2732-494X |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2021 |
| الوصف: | Background: NDM/OXA-23 carbapenemase-producing Acinetobacter baumannii isolates have been reported worldwide, but rarely in the United States. A California acute-care hospital (ACH) A identified 3 patients with pan-nonsusceptible A. baumannii during May–June 2020, prompting a public health investigation to prevent further transmission among the regional healthcare network. Methods: A clinical isolate was defined as NDM/OXA-23–producing A. baumannii from a patient at ACH A or B, or an epidemiologically linked patient identified through colonization screening during May 2020–January 2021. ACHs A and B are sentinel sites for carbapenem-resistant A. baumannii surveillance through the Antibiotic Resistance Laboratory Network (AR Lab Network), where isolates are tested for carbapenemase genes. The California Department of Public Health with 3 local health departments conducted an epidemiological investigation, contact tracing, colonization screening, and whole-genome sequencing (WGS). Results: In total, 11 cases were identified during May 2020–January 2021, including 3 cases at ACH A during May–June 2020, and 8 additional cases during November 2020–January 2021: 5 at ACH A, 1 at ACH B, and 2 at skilled nursing facility (SNF) A. Isolates from ACHs A and B were identified through testing at the AR Lab Network. Of the 11 patients (including the index patient), 4 had exposure at SNF A, where 2 cases were identified through colonization screening. Screening conducted at ACH A and 5 other long-term care facilities (LTCFs) identified no additional cases. WGS results for the first 8 cases identified showed 2–13 single-nucleotide polymorphism differences. Antibiotic resistance genes for all isolates sequenced included NDM-1 and OXA-23. On-site assessments related to a COVID-19 outbreak conducted at ACH A identified infection control gaps. Conclusions: Hospital participation in public health laboratory surveillance allows early detection of novel multidrug-resistant organisms (MDROs), which enabled outbreak identification and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/ash.2021.155 |
| الاتاحة: | http://dx.doi.org/10.1017/ash.2021.155 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2732494X21001558 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.B9CBF9E3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/ash.2021.155 |
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