Academic Journal
Clinical and molecular features of epidermal growth factor receptor (Egfr) mutation positive non‐small‐cell lung cancer (nsclc) patients treated with tyrosine kinase inhibitors (tkis): Predictive and prognostic role of co‐mutations
| العنوان: | Clinical and molecular features of epidermal growth factor receptor (Egfr) mutation positive non‐small‐cell lung cancer (nsclc) patients treated with tyrosine kinase inhibitors (tkis): Predictive and prognostic role of co‐mutations |
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| المؤلفون: | Bironzo P., Reale M. L., Sperone T., Tabbo F., Caglio A., Listi A., Passiglia F., Di Maio M., Righi L., Bussolino F., Scagliotti G. V., Novello S. |
| المساهمون: | Bironzo P., Reale M.L., Sperone T., Tabbo F., Caglio A., Listi A., Passiglia F., Di Maio M., Righi L., Bussolino F., Scagliotti G.V., Novello S. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | Co‐mutation, Epidermal growth factor receptor (EGFR), Next‐generation sequencing (NGS), Non‐small‐cell lung cancer (NSCLC), Tyrosine kinase inhibitors (TKIs) |
| الوصف: | Background: Tyrosine kinase inhibitors (TKIs) show variable efficacy in epidermal growth factor receptor mutation‐positive (EGFR+) NSCLC patients, even in patients harbouring the same mutation. Co‐alterations may predict different outcomes to TKIs. Methods: We retrospectively analysed all consecutive EGFR+ advanced NSCLC treated with first‐line TKIs at our Institutions. NGS with a 22 genes clinical panel was performed on diagnostic specimens. PD‐L1 expression was also evaluated. Results: Of the 106 analysed specimens, 59 showed concomitant pathogenic mutations. No differences in OS (mOS 22.8 vs. 29.5 months; p = 0.088), PFS (mPFS 10.9 vs. 11.2 months; p = 0.415) and ORR (55.9% vs. 68.1%; p = 0.202) were observed comparing patients without and with co‐alterations. Subgroup analysis by EGFR mutation type and TKIs generation (1st/2nd vs. 3rd) did not show any difference too. No correlations of PD‐L1 expression levels by co-mutational status were found. Significant associations with presence of co‐alterations and younger age (p = 0.018) and baseline lymph nodes metastases (p = 0.032) were observed. Patients without concomitant alterations had a significant higher risk of bone progression (26.5% vs. 3.3%, p = 0.011). Conclusions: Pathogenic co‐alterations does not seem to predict survival nor efficacy of EGFR TKIs in previously untreated advanced NSCLC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34067823; info:eu-repo/semantics/altIdentifier/wos/WOS:000654640500001; volume:13; issue:10; firstpage:///; lastpage:///; numberofpages:///; journal:CANCERS; http://hdl.handle.net/2318/1790638; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105779071 |
| DOI: | 10.3390/cancers13102425 |
| الاتاحة: | http://hdl.handle.net/2318/1790638 https://doi.org/10.3390/cancers13102425 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B9C88918 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers13102425 |
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