Academic Journal

Human regulatory B cells in health and disease:therapeutic potential

التفاصيل البيبلوغرافية
العنوان: Human regulatory B cells in health and disease:therapeutic potential
المؤلفون: Mauri, Claudia, Menon, Madhvi
المصدر: Mauri , C & Menon , M 2017 , ' Human regulatory B cells in health and disease : therapeutic potential ' , The Journal of clinical investigation , vol. 127 , no. 3 , pp. 772-779 . https://doi.org/10.1172/JCI85113
سنة النشر: 2017
المجموعة: The University of Manchester: Research Explorer - Publications
مصطلحات موضوعية: Animals, B-Lymphocytes, Regulatory/immunology, Humans, Immune System Diseases/immunology, Immunotherapy/methods, Interleukin-10/immunology
الوصف: Regulatory B cells (Bregs) modulate immune responses predominantly, although not exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of immune homeostasis comes from a variety of immune-related pathologies, such as autoimmune diseases, cancers, and chronic infections that are often associated with abnormalities in Breg numbers or function. A continuous effort toward understanding Breg biology in healthy individuals will provide new opportunities to develop Breg immunotherapy that could prove beneficial in treating various immune-mediated pathologies. In this Review, we discuss findings regarding human Bregs, including their mechanisms of suppression and role in different disease settings. We also propose several therapeutic strategies targeting Bregs for better management of immune disorders.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1172/JCI85113
الاتاحة: https://research.manchester.ac.uk/en/publications/fc916136-e03e-47b9-a9c6-d1f7fda3023a
https://doi.org/10.1172/JCI85113
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.B945C484
قاعدة البيانات: BASE