Academic Journal
Evaluation of Genotypic Antiviral Resistance Testing as an Alternative to Phenotypic Testing in a Patient with DOCK8 Deficiency and Severe HSV-1 Disease
| العنوان: | Evaluation of Genotypic Antiviral Resistance Testing as an Alternative to Phenotypic Testing in a Patient with DOCK8 Deficiency and Severe HSV-1 Disease |
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| المؤلفون: | Casto, Amanda M, Stout, Sean C, Selvarangan, Rangaraj, Freeman, Alexandra F, Newell, Brandon D, Stahl, Erin D, Ahmed, Atif A, Greninger, Alexander L, Yin, Dwight E |
| المساهمون: | National Institute of Allergy and Infectious Diseases |
| المصدر: | The Journal of Infectious Diseases ; volume 221, issue 12, page 2035-2042 ; ISSN 0022-1899 1537-6613 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| الوصف: | Antiviral resistance frequently complicates the treatment of herpes simplex virus (HSV) infections in immunocompromised patients. Here we present the case of an adolescent boy with dedicator of cytokinesis 8 (DOCK8) deficiency, who experienced recurrent infections with resistant HSV-1. We used both phenotypic and genotypic methodologies to characterize the resistance profile of HSV-1 in the patient and conclude that genotypic testing outperformed phenotypic testing. We also present the first analysis of intrahost HSV-1 evolution in an immunocompromised patient. While HSV-1 can remain static in an immunocompetent individual for decades, the virus from this patient rapidly acquired genetic changes throughout its genome. Finally, we document a likely case of transmitted resistance in HSV-1 between the patient and his brother, who also has DOCK8 deficiency. This event demonstrates that resistant HSV-1 is transmissible among immunocompromised persons. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/infdis/jiaa020 |
| DOI: | 10.1093/infdis/jiaa020/31928076/jiaa020.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/infdis/jiaa020 http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa020/31928076/jiaa020.pdf http://academic.oup.com/jid/article-pdf/221/12/2035/33379760/jiaa020.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.B940565A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/jiaa020 |
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