Academic Journal
Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology
| العنوان: | Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology |
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| المؤلفون: | Newell R. Washburn, Carl G. Simon, Ro Tona, Hoda M. Elgendy, Alamgir Karim, Eric J. Amis |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://matdl.org/repository/eserv/matdl:514/washburn0102.pdf. |
| سنة النشر: | 2002 |
| المجموعة: | CiteSeerX |
| الوصف: | A methodology for the preparation of porous scaffolds for tissue engineering using co-extrusion is pre-sented. Poly(-caprolactone) is blended with poly(ethylene oxide) in a twin-screw extruder to form a two-phase mate-rial with micron-sized domains. Selective dissolution of the poly(ethylene oxide) with water results in a porous material. A range of blend volume fractions results in co-continuous networks of polymer and void spaces. Annealing studies demonstrate that the characteristic pore size may be in-creased to larger than 100 m. The mechanical properties of the scaffolds are characterized by a compressive modulus on the order of 1 MPa at low strains but displaying a marked strain-dependence. The results of osteoblast seeding suggest it is possible to use co-extrusion to prepare polymer scaf-folds without the introduction of toxic contaminants. Poly-mer co-extrusion is amenable to both laboratory- and indus-trial-scale production of scaffolds for tissue engineering and only requires rheological characterization of the blend com-ponents. This method leads to scaffolds that have continu-ous void space and controlled characteristic length scales without the use of potentially toxic organic solvents. © 2002 |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.490.1066; http://matdl.org/repository/eserv/matdl:514/washburn0102.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.490.1066 http://matdl.org/repository/eserv/matdl:514/washburn0102.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.B913C619 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |