التفاصيل البيبلوغرافية
| العنوان: |
Leveraging Trifluoromethylated Benzyl Groups toward the Highly 1,2- Cis -Selective Glucosylation of Reactive Alcohols |
| المؤلفون: |
Dancan K. Njeri (11596272), Erik Alvarez Valenzuela (11596275), Justin R. Ragains (1266825) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Biotechnology, Evolutionary Biology, Infectious Diseases, Virology, Computational Biology, trifluoromethylbenzyl vs 3, glucosyl imidate donors, >- trifluoromethylbenzyl ), >- selective glucosylation, reactive alcohol acceptors, observe high 1, >- selectivity, reactive alcohols, triphenylphosphine oxide, trifluoromethyl results, trifluoromethyl groups, substantial increase, particularly encouraging, highly 1, cis <, bis <, benzyl groups, 5 -<, 2 -< |
| الوصف: |
Here, we demonstrate that substitution of the benzyl groups of glucosyl imidate donors with trifluoromethyl results in a substantial increase in 1,2- cis -selectivity when activated with TMS-I in the presence of triphenylphosphine oxide. Stereoselectivity is dependent on the number of trifluoromethyl groups (4-trifluoromethylbenzyl vs 3,5- bis -trifluoromethylbenzyl). Particularly encouraging is that we observe high 1,2- cis -selectivity with reactive alcohol acceptors. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Leveraging_Trifluoromethylated_Benzyl_Groups_toward_the_Highly_1_2-_i_Cis_i_-Selective_Glucosylation_of_Reactive_Alcohols/16860045 |
| DOI: |
10.1021/acs.orglett.1c02947.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.orglett.1c02947.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.B8D5F13A |
| قاعدة البيانات: |
BASE |