التفاصيل البيبلوغرافية
| العنوان: |
Can clinicopathological factors improve the prediction of metastasis to nonsentinel lymph nodes in patients with breast cancer? |
| المؤلفون: |
García-Mejido,José A., Sánchez-Sevilla,Miguel, González-Martínez,Jesús, Fernández-Palacín,Ana, Sainz-Bueno,José A. |
| المصدر: |
Cirugía y cirujanos v.90 n.4 2022 |
| بيانات النشر: |
Academia Mexicana de Cirugía A.C. |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Carcinoma breast cancer, Sentinel lymph node/SLN, Nucleic acid amplification/OSNA, Tumor load CK19 |
| الوصف: |
Introduction: To determine whether clinicopathological characteristics can improve the prediction of metastasis to nonsentinel lymph nodes (NSLNs) over the use of only mRNA copy number in sentinel lymph node (SLN) biopsies. Methods: This was a retrospective, observational study that included a total of 824 patients with T1-3 breast cancer who had clinically negative, ultrasound-negative axilla without evidence of metastasis and who underwent one-step nucleic acid amplification in SLN biopsies. Results: 118 required a complete axillary lymph node dissection (ALNhD). About 35.6% (42/118) had metastases to a NSLN, and 64.4% (76/118) had no metastasis to a NSLN. The ROC curve of the total tumor load (TTL) presented an area under the curve (AUC) of 0.651 (95%; CI: 0.552-0.751). The 7294 copies of CK19 mRNA were established as the optimal cutoff point, with sensitivity: 93%, specificity: 63%, positive predictive value: 44%, and negative predictive value: 91%. By associating the clinicopathological parameters (multicentricity, pooled immunohistochemistry [IHC], and progesterone receptors), the AUC went up to 0.752 (95% CI: 0.663-0.841). Conclusions: Clinicopathological factors should be considered together with the total CK19 mRNA copy number (the TTL) of the SLNs to improve the predictive capacity of metastatic involvement of the NSLNs. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
text/html |
| اللغة: |
English |
| الاتاحة: |
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2444-054X2022000400473 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.B8D314AF |
| قاعدة البيانات: |
BASE |