Academic Journal
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults
| العنوان: | Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
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| المؤلفون: | Björn H. Schott, Joram Soch, Jasmin M. Kizilirmak, Hartmut Schütze, Anne Assmann, Anne Maass, Gabriel Ziegler, Magdalena Sauvage, Anni Richter |
| المصدر: | iScience, Vol 26, Iss 10, Pp 107765- (2023) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Behavioral neuroscience, Cognitive neuroscience, Neuroscience, Techniques in neuroscience, Science |
| الوصف: | Summary: Successful explicit memory encoding is associated with inferior temporal activations and medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal modeling (DCM) of functional magnetic resonance imaging data to elucidate effective connectivity patterns between hippocampus, parahippocampal place area (PPA), and precuneus during encoding of novel visual scenes. In 117 young adults, DCM revealed pronounced activating input from the PPA to the hippocampus and inhibitory connectivity from the PPA to the precuneus during novelty processing, with both being enhanced during successful encoding. This pattern could be replicated in two cohorts (N = 141 and 148) of young and older adults. In both cohorts, older adults selectively exhibited attenuated inhibitory PPA-precuneus connectivity, which correlated negatively with memory performance. Our results provide insight into the network dynamics underlying explicit memory encoding and suggest that age-related differences in memory-related network activity are, at least partly, attributable to altered temporo-parietal neocortical connectivity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2589-0042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2589004223018424; https://doaj.org/toc/2589-0042; https://doaj.org/article/c4e5d1b5b9674b2aa7cd2eb69f2fc775 |
| DOI: | 10.1016/j.isci.2023.107765 |
| الاتاحة: | https://doi.org/10.1016/j.isci.2023.107765 https://doaj.org/article/c4e5d1b5b9674b2aa7cd2eb69f2fc775 |
| رقم الانضمام: | edsbas.B8CEF15B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25890042 |
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| DOI: | 10.1016/j.isci.2023.107765 |