Academic Journal
Prediction model for hypertension in first decade after pre-eclampsia in initially normotensive women
| العنوان: | Prediction model for hypertension in first decade after pre-eclampsia in initially normotensive women |
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| المؤلفون: | Hooijschuur, M. C.E., Janssen, E. B.N.J., Mulder, E. G., Kroon, A. A., Meijers, J. M.J., Brugts, J. J., Van Bussel, B. C.T., Van Kuijk, S. M.J., Spaanderman, M. E.A., Ghossein-Doha, C. |
| المصدر: | Hooijschuur , M C E , Janssen , E B N J , Mulder , E G , Kroon , A A , Meijers , J M J , Brugts , J J , Van Bussel , B C T , Van Kuijk , S M J , Spaanderman , M E A & Ghossein-Doha , C 2023 , ' Prediction model for hypertension in first decade after pre-eclampsia in initially normotensive women ' , Ultrasound in Obstetrics and Gynecology , vol. 62 , no. 4 , pp. 531-539 . https://doi.org/10.1002/uog.26284 |
| سنة النشر: | 2023 |
| الوصف: | Objective: To develop a prediction model for the development of hypertension in the decade following pre-eclampsia in women who were normotensive shortly after pregnancy. Methods : This was a longitudinal cohort study of formerly pre-eclamptic women attending a university hospital in The Netherlands between 1996 and 2019. We developed a prediction model for incident hypertension using multivariable logistic regression analysis. The model was validated internally using bootstrapping techniques. Results: Of 259 women, 185 (71%) were normotensive at the first cardiovascular assessment, at a median of 10 (interquartile range (IQR), 6–24) months after a pre-eclamptic pregnancy, of whom 49 (26%) had developed hypertension by the second visit, at a median of 11 (IQR, 6–14) years postpartum. The prediction model, based on birth-weight centile, mean arterial pressure, total cholesterol, left ventricular mass index and left ventricular ejection fraction, had good-to-excellent discriminative ability, with an area under the receiver-operating-characteristics curve (AUC) of 0.82 (95% CI, 0.75–0.89) and an optimism-corrected AUC of 0.80. The sensitivity and specificity of our model to predict hypertension were 98% and 34%, respectively, and positive and negative predictive values were 35% and 98%, respectively. Conclusions: Based on five variables, we developed a good-to-excellent predictive tool to identify incident hypertension following pre-eclampsia in women who were normotensive shortly after pregnancy. After external validation, this model could have considerable clinical utility in tackling the cardiovascular legacy of pre-eclampsia. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1002/uog.26284 |
| الاتاحة: | https://pure.eur.nl/en/publications/905c945d-b01a-44ee-a603-3752056b3d41 https://doi.org/10.1002/uog.26284 https://pure.eur.nl/ws/files/104360091/Prediction_model_for_hypertension_in_first_decade_after_pre-eclampsia_in_initially_normotensive_women.pdf http://www.scopus.com/inward/record.url?scp=85173785020&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B8CC0F38 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/uog.26284 |
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