Academic Journal
The New Era for Reno-Cardiovascular Treatment in Type 2 Diabetes
| العنوان: | The New Era for Reno-Cardiovascular Treatment in Type 2 Diabetes |
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| المؤلفون: | García Carro, Clara, Vergara Arana, Ander, Agraz Pamplona, Irene, Jacobs Cachá, Concepció, Espinel Garuz, María Eugenia, Serón Micas, Daniel, Soler Romeo, Maria Jose |
| المساهمون: | Institut Català de la Salut, García-Carro C, Vergara A Grup de Recerca en Nefrologia, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de Nefrologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Agraz I, Jacobs-Cachá C, Espinel E, Seron D, Soler MJ Grup de Recerca en Nefrologia, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de Nefrologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Red de Investigación Renal (REDINREN), Instituto Carlos III, Madrid, Spain., Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Nefropaties diabètiques - Fisiologia patològica, Antidiabètics - Ús terapèutic, Nefropaties diabètiques - Tractament, DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Nephropathies, Other subheadings::Other subheadings::/physiology, Other subheadings::Other subheadings::Other subheadings::/drug therapy, CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents::Dipeptidyl-Peptidase IV Inhibitors, Other subheadings::Other subheadings::/therapeutic use, ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::nefropatías diabéticas, Otros calificadores::Otros calificadores::/fisiología, Otros calificadores::Otros calificadores::Otros calificadores::/tratamiento farmacológico, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::hipoglicemiantes::inhibidores de la dipeptidil-peptidasa IV, Otros calificadores::Otros calificadores::/uso terapéutico |
| الوصف: | Diabetes; Diabetic kidney disease; Dipeptidyl peptidase 4 inhibitors ; Diabetis; Nefropatia diabètica; Inhibidors de la dipeptidil peptidasa 4 ; Diabetes; Nefropatía diabética; Inhibidores de la dipeptidil peptidasa 4 ; Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease in the developed world. Until 2016, the only treatment that was clearly demonstrated to delay the DKD was the renin-angiotensin system blockade, either by angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. However, this strategy only partially covered the DKD progression. Thus, new strategies for reno-cardiovascular protection in type 2 diabetic patients are urgently needed. In the last few years, hypoglycaemic drugs, such as sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists, demonstrated a cardioprotective effect, mainly in terms of decreasing hospitalization for heart failure and cardiovascular death in type 2 diabetic patients. In addition, these drugs also demonstrated a clear renoprotective effect by delaying DKD progression and decreasing albuminuria. Another hypoglycaemic drug class, dipeptidyl peptidase 4 inhibitors, has been approved for its use in patients with advanced chronic kidney disease, avoiding, in part, the need for insulinization in this group of DKD patients. Studies in diabetic and non-diabetic experimental models suggest that these drugs may exert their reno-cardiovascular protective effect by glucose and non-glucose dependent mechanisms. This review focuses on newly demonstrated strategies that have shown reno-cardiovascular benefits in type 2 diabetes and that may change diabetes management algorithms. ; The authors are current recipients of research grants from the FONDO DE INVESTIGACIÓN SANITARIA-FEDER, ISCIII, PI17/00257, and REDINREN, RD16/0009/0030. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| Relation: | Journal of Clinical Medicine;8(6); https://www.mdpi.com/2077-0383/8/6/864; García-Carro C, Vergara A, Agraz I, Jacobs-Cachá C, Espinel E, Seron D, et al. The New Era for Reno-Cardiovascular Treatment in Type 2 Diabetes. J Clin Med. 2019;8(6):e864.; https://hdl.handle.net/11351/4235; WOS:000475349300108 |
| DOI: | 10.3390/jcm8060864 |
| الاتاحة: | https://hdl.handle.net/11351/4235 https://doi.org/10.3390/jcm8060864 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B8AD5F19 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm8060864 |