Academic Journal
Were We Able to Reduce Cardiac Doses in Breast Cancer Radiotherapy Over Time?
| العنوان: | Were We Able to Reduce Cardiac Doses in Breast Cancer Radiotherapy Over Time? |
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| المؤلفون: | Pelin Altınok, Latif Korkmaz, Ayse Altınok, Nuran Beşe |
| المصدر: | European Journal of Breast Health, Vol 17, Iss 2, Pp 145-149 (2021) |
| بيانات النشر: | Galenos Publishing House |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | breast cancer, radiotherapy, cardiac toxicity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Medicine |
| الوصف: | Objective:In this study, we aimed to review the heart and left coronary artery doses over the years in patients who received breast cancer radiotherapy (RT).Materials and Methods:A total of 436 breast cancer patients of 2 RT centers treated between the years 2010 and 2018 were included. The mean heart doses (HeartDmean-HDM) and left coronary artery mean doses (LDM) were analyzed using nonparametric tests. The conventional RT (CRT) was 50 Gy/2 Gy in 5 weeks, and the hypofractionated RT (HRT) was 40.05 Gy/2.67 Gy in 3 weeks. Boost was applied as 10–16 Gy/2 Gy for CRT and 10 Gy/2.5 Gy for HRT. An equivalent conventional total dose of 2 Gy/fraction (EQD2) was taken into account for HRT.Results:HDM was 107±104 cGy, and LDM was 288±209 cGy for the entire group. HDM was significantly lower in patients with breast-conserving surgery (99±94 cGy) than that in those with mastectomy (128±124 cGy) (p<0.001). Field-in-field intensity-modulated RT technique significantly reduced the doses compared to volumetric applications (104±95 cGy vs 141±38 cGy; p = 0.002). HDM was significantly increased with lymphatic RT (132±58 cGy vs 112±115 cGy; p<0.001). The addition of internal mammary volumes significantly increased HDM (p<0.001). No significant effect of boost was observed (p = 0.96). For both CRT and HRT regimens, HDM values were significantly lower after the year 2014 (right side p<0.001, left side p = 0.01). In the left side CRT, HDM was 1.74 Gy before 2014 and 1.3 Gy after 2014 and 1.0 and 1.19 Gy, respectively, for the right side.Conclusion:All efforts to reduce the cardiac doses will likely reduce long-term side effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2587-0831 |
| Relation: | http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/were-we-able-to-reduce-cardiac-doses-in-breast-can/47124; https://doaj.org/toc/2587-0831; https://doaj.org/article/e5f72749b446486bb685b6cae51d48db |
| DOI: | 10.4274/ejbh.galenos.2021.6148 |
| الاتاحة: | https://doi.org/10.4274/ejbh.galenos.2021.6148 https://doaj.org/article/e5f72749b446486bb685b6cae51d48db |
| رقم الانضمام: | edsbas.B8A93F4C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25870831 |
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| DOI: | 10.4274/ejbh.galenos.2021.6148 |