Academic Journal
Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota
| العنوان: | Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota |
|---|---|
| المؤلفون: | Lê, Sylvie, Laurencin, Sara, Minty, Matthieu, Assoulant-Anduze, Justine, Vinel, Alexia, Yanat, Noor, Loubieres, Pascale, Azalbert, Vincent, Diemer, Swann, Burcelin, Rémy, Canceill, Thibault, Thomas, Charlotte, Blasco-Baque, Vincent |
| المساهمون: | Service Odontologie et traitement dentaire - Hôtel-Dieu Saint-Jacques CHU Toulouse, Pôle Clinique des Voies respiratoires CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Odontologie et traitement dentaire - Faculté de chirurgie dentaire CHU Toulouse, Equipe SPHERE (CERPOP), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3) |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | CCSD MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | oral microbiota, subgingival microbiota, periodontitis, obesity, periodontal inflammation, PISA, periodontal treatment response, MESH: Humans, MESH: Cohort Studies, MESH: Bacteria, MESH: Periodontitis, MESH: Inflammation, MESH: Microbiota, MESH: Obesity, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; The aim of this study was to analyze the link between periodontal microbiota and obesity in humans. We conducted a cohort study including 45 subjects with periodontitis divided into two groups: normo-weighted subjects with a body mass index (BMI) between 20 and 25 kg/m2 (n = 34) and obese subjects with a BMI > 30 kg/m2 (n = 11). Our results showed that obesity was associated with significantly more severe gingival inflammation according to Periodontal Inflamed Surface Area (PISA index). Periodontal microbiota taxonomic analysis showed that the obese (OB) subjects with periodontitis were characterized by a specific signature of subgingival microbiota with an increase in Gram-positive bacteria in periodontal pockets, associated with a decrease in microbiota diversity compared to that of normo-weighted subjects with periodontitis. Finally, periodontal treatment response was less effective in OB subjects with persisting periodontal inflammation, reflecting a still unstable periodontal condition and a risk of recurrence. To our knowledge, this study is the first exploring both salivary and subgingival microbiota of OB subjects. Considering that OB subjects are at higher periodontal risk, this could lead to more personalized preventive or therapeutic strategies for obese patients regarding periodontitis through the specific management of oral microbiota of obese patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37894804; PUBMED: 37894804; PUBMEDCENTRAL: PMC10606428 |
| DOI: | 10.3390/ijms242015123 |
| الاتاحة: | https://hal.science/hal-04824980 https://hal.science/hal-04824980v1/document https://hal.science/hal-04824980v1/file/Le_2023.pdf https://doi.org/10.3390/ijms242015123 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B8A2190D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms242015123 |
|---|