Academic Journal
The partial adaptation strategy for online‐adaptive proton therapy: A proof of concept study in head and neck cancer patients
| العنوان: | The partial adaptation strategy for online‐adaptive proton therapy: A proof of concept study in head and neck cancer patients |
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| المؤلفون: | Gambetta, Virginia, Fredriksson, Albin, Menkel, Stefan, Richter, Christian, Stützer, Kristin |
| المصدر: | Medical Physics ; volume 51, issue 8, page 5572-5581 ; ISSN 0094-2405 2473-4209 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background The accuracy of intensity‐modulated proton therapy (IMPT) is greatly affected by anatomy variations that might occur during the treatment course. Online plan adaptations have been proposed as a solution to intervene promptly during a treatment session once the anatomy changes are detected. The implementation of online‐adaptive proton therapy (OAPT) is still hindered by time‐consuming tasks in the workflow. Purpose The study introduces the novel concept of partial adaptation and aims at investigating its feasibility as a potential solution to parallelize tasks during an OAPT workflow for saving valuable in‐room time. Methods The proof‐of‐principle simulation study includes datasets from six head and neck cancer (HNC) patients, each consisting of one planning CT (pCT) and three contoured control CTs (cCTs). Robust 3‐field normo‐fractionated initial IMPT plans were generated on the pCTs with a standardized field configuration, delivering 66 Gy and 54 Gy to the high‐risk and low‐risk clinical target volume (CTV High and CTV Low ), respectively. For each cCT, a dose‐mimicking‐based partial adaptation was applied: two fields were adapted on the current anatomy taking into account the background dose of the first non‐adapted field supposedly delivered in the meantime. Fraction doses on the cCTs resulting from partially adapted plans with different first (non‐adapted) field assignments were compared against those from non‐adapted and fully adapted plans regarding target coverage and organs at risk (OARs) sparing. The robustness of partially adapted plans was also evaluated. Results Partially adapted plans showed comparable results to fully adapted plans and were superior to non‐adapted plans for both target coverage and OAR sparing. Target coverage degradation in the non‐adapted plans (median D 98% : 95.9% and 97.5% for CTV Low and CTV High , respectively) was recovered by both partial (98.0% and 98.5%) and full adaptation (98.2% and 98.7%) in comparison to the initial plans (98.7% and 98.8%). The ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/mp.17178 |
| الاتاحة: | http://dx.doi.org/10.1002/mp.17178 https://aapm.onlinelibrary.wiley.com/doi/pdf/10.1002/mp.17178 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.B89AEB1F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mp.17178 |
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