Academic Journal
PULSE WAVE VELOCITY IS CORRELATED WITH PLASMA CREATININE LEVELS AND GLOMERULAR FILTRATION RATE IN PATIENTS WITH CARDIOVASCULAR RISK FACTORS
| العنوان: | PULSE WAVE VELOCITY IS CORRELATED WITH PLASMA CREATININE LEVELS AND GLOMERULAR FILTRATION RATE IN PATIENTS WITH CARDIOVASCULAR RISK FACTORS |
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| المؤلفون: | Baba, Mirela, Bucur, Adina, Maris, Mihaela, Jianu, Daniela, Luca, Constantin Tudor, Moroz, Simina Mariana, Stoian, Dana, Mozos, Ioana |
| المصدر: | Journal of Hypertension ; volume 42, issue Suppl 1, page e216 ; ISSN 0263-6352 1473-5598 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2024 |
| الوصف: | Objective: Scientific evidence suggests that the kidneys’ role in hypertension is mostly linked to the association between mean arterial pressure (MAP) and vascular resistance. In recent publications, two key indicators of arterial stiffness, pulse pressure (PP) and pulse wave velocity (PWV) have been found to be important predictors of the cardiovascular risk and decline in glomerular filtration rate (GFR). We aimed to study the relationship between variables of pulse wave analysis and renal function in patients with cardiovascular risk factors. Design and method: Our cross-sectional, descriptive study included patients referred to the clinic within a National Screening Programme for cardiovascular risk factors. The patients underwent anthropomorphic measurements, office blood pressure measurements, pulse wave analysis using a Mobil-O-Graph and standard blood tests such as lipids, glucose and creatinine. Results: 76 patients entered the study aged 63±10 years, 53% males, 47% females, mean systolic blood pressure (SBP) of 133.8 mmHg (±18.8), mean diastolic blood pressure (DBP) of 84.1mmHg (±11.5), mean arterial pressure (MAP) of 105.6mmHg (±17.7), mean pulse pressure (PP) of 49.8mmHg (±13.2), mean pulse wave velocity (PWV) of 9.3m/s (±1.5) and mean augmentation index (AI) of 24.7 (±16.2). In linear regression analysis, blood creatinine level was significantly correlated with PWV (r= 0.328, p= 0.004), PP (r= 0.249, p= 0.03), MAP (r= 0.297, p= 0.009), SBP (r= 0.337, p= 0.003) and DBP (r= 0.267, p= 0.02). Glomerular filtration rate (GFR) was significantly negatively correlated with PWV (r= -0.465, p= 0.0001) and SBP (r= -0.227, p= 0.049). Multiple regression analysis revealed significant associations of creatinine with PWV and SBP (multiple correlation coefficient (MCC) = 0.402, p=0.0016) and GFR with PWV after adjusting for SBP (MCC = 0.468, p<0.0001). Conclusions: Pulse wave velocity can predict blood creatinine and glomerular filtration rate in patients with cardiovascular risk factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/01.hjh.0001021656.38410.3e |
| الاتاحة: | http://dx.doi.org/10.1097/01.hjh.0001021656.38410.3e https://journals.lww.com/10.1097/01.hjh.0001021656.38410.3e |
| رقم الانضمام: | edsbas.B886EE77 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/01.hjh.0001021656.38410.3e |
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