Academic Journal
Is muscle and protein loss relevant in long‐term fasting in healthy men? A prospective trial on physiological adaptations
| العنوان: | Is muscle and protein loss relevant in long‐term fasting in healthy men? A prospective trial on physiological adaptations |
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| المؤلفون: | Laurens, Claire, Grundler, Franziska, Damiot, Anthony, Chery, Isabelle, Le Maho, Anne‐Laure, Zahariev, Alexandre, Le Maho, Yvon, Bergouignan, Audrey, Gauquelin‐Koch, Guillemette, Simon, Chantal, Blanc, Stéphane, Wilhelmi de Toledo, Françoise |
| المساهمون: | Conseil National de la Recherche Scientifique |
| المصدر: | Journal of Cachexia, Sarcopenia and Muscle ; volume 12, issue 6, page 1690-1703 ; ISSN 2190-5991 2190-6009 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Fasting is attracting an increasing interest as a potential strategy for managing diseases, including metabolic disorders and complementary cancer therapy. Despite concerns of clinicians regarding protein catabolism and muscle loss, evidence‐based clinical data in response to long‐term fasting in healthy humans are scarce. The objective of this study was to measure clinical constants, metabolic, and muscular response in healthy men during and after a 10 day fast combined with a physical activity programme. Methods Sixteen men (44 ± 14 years; 26.2 ± 0.9 kg/m 2 ) fasted with a supplement of 200–250 kcal/day and up to 3 h daily low‐intensity physical activity according to the peer‐reviewed Buchinger Wilhelmi protocol. Changes in body weight (BW) and composition, basal metabolic rate (BMR), physical activity, muscle strength and function, protein utilization, inflammatory, and metabolic status were assessed during the 10 day fast, the 4 days of food reintroduction, and at 3 month follow‐up. Results The 10 day fast decreased BW by 7% (−5.9 ± 0.2 kg, P < 0.001) and BMR by 12% ( P < 0.01). Fat mass and lean soft tissues (LST) accounted for about 40% and 60% of weight loss, respectively, −2.3 ± 0.18 kg and −3.53 ± 0.13 kg, P < 0.001. LST loss was explained by the reduction in extracellular water (44%), muscle and liver glycogen and associated water (14%), and metabolic active lean tissue (42%). Plasma 3‐methyl‐histidine increased until Day 5 of fasting and then decreased, suggesting that protein sparing might follow early proteolysis. Daily steps count increased by 60% ( P < 0.001) during the fasting period. Strength was maintained in non‐weight‐bearing muscles and increased in weight‐bearing muscles (+33%, P < 0.001). Glycaemia, insulinemia, blood lipids, and blood pressure dropped during the fast ( P < 0.05 for all), while non‐esterified fatty acids and urinary beta‐hydroxybutyrate increased ( P < 0.01 for both). After a transient reduction, inflammatory cytokines returned to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jcsm.12766 |
| الاتاحة: | http://dx.doi.org/10.1002/jcsm.12766 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcsm.12766 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcsm.12766 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.B8617FA2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jcsm.12766 |
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