Academic Journal
Silicon Oxynitride Coatings Are Very Promising for Inert and Durable Pharmaceutical Glass Vials
| العنوان: | Silicon Oxynitride Coatings Are Very Promising for Inert and Durable Pharmaceutical Glass Vials |
|---|---|
| المؤلفون: | Konstantina Christina Topka, Babacar Diallo, Maxime Puyo, Erwan Chesneau, Farah Inoubli, Simon Ponton, Cecile Genevois, Diane Samelor, Raphael Laloo, Daniel Sadowski, Cédric Charvillat, Takashi Teramoto, François Senocq, Thierry Sauvage, Hugues Vergnes, Marie-Joelle Menu, Christian Dussarrat, Brigitte Caussat, Viviane Turq, Constantin Vahlas, Nadia Pellerin |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biophysics, Molecular Biology, Biotechnology, Ecology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, novel medicinal molecules, fine structural determination, achieved barrier properties, 580 ° c, providing chemical inertness, silicon oxynitride coatings, – n network, si –, applying chemical, silicate network, surface coatings, stored drug, possibility utilizing, nitrogen substitution, multiple applications, internal surface, glass network, films confirm, excellent performance, constituent elements, coatings pave, atomistic modeling |
| الوصف: | Glass packaging of novel medicinal molecules is challenged by hydrolysis of the glass network from an interaction with the stored drug, likely to result in leaching of constituent elements of the glass into the solution. We have succeeded in applying chemical-vapor-deposited silicon oxynitride coatings from a highly reactive trisilylamine derivative molecule as a precursor, at a temperature below 580 °C, opening up the possibility utilizing such coatings on glass surfaces. We demonstrate that such silicon oxynitride coatings applied on the internal surface of pharmaceutical vials prevent degradation, providing chemical inertness and withstanding severe screening conditions of the United States Pharmacopeia USP <1660> chapter. Fine structural determination and atomistic modeling of the Si–O–N network of the films confirm the nitrogen substitution of oxygen and densification of the silicate network through the addition of the former. The achieved barrier properties and excellent performance of these coatings pave the way toward sustainable packaging with improved product shelf life, transferable to multiple applications of surface coatings. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Silicon_Oxynitride_Coatings_Are_Very_Promising_for_Inert_and_Durable_Pharmaceutical_Glass_Vials/24632343 |
| DOI: | 10.1021/acsaenm.3c00584.s001 |
| الاتاحة: | https://doi.org/10.1021/acsaenm.3c00584.s001 https://figshare.com/articles/journal_contribution/Silicon_Oxynitride_Coatings_Are_Very_Promising_for_Inert_and_Durable_Pharmaceutical_Glass_Vials/24632343 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.B859FE55 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsaenm.3c00584.s001 |
|---|