التفاصيل البيبلوغرافية
| العنوان: |
A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine |
| المؤلفون: |
Martens, Daan, Ramirez Priego, Patricia, Murib, M. S., Elamin, Ayssar A., González-Guerrero, Ana Belén, Stehr, M., Jonas, F., Anton, Birgit, Hlawatsch, N., Soetaert, Pieterjan, Vos, Rita, Stassen, A., Severi, S., Van Roy, Wim, Bockstaele, Ronny, Becker, Holger, Singh, Mahavir, Lechuga, Laura M, Bienstman, Peter |
| سنة النشر: |
2018 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Biosensing platforms, Evanescent wave sensors, Nitride materials, On board softwares, Polymer microfluidics, Real time analysis, Refractive index units, State of the art |
| الوصف: |
We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis. The sensor chip included in the platform contains multiplexed Mach-Zehnder interferometers with an on-chip optical spectral analyser consisting of an arrayed-waveguide grating. The sensor chip is fabricated in silicon nitride material, which makes it compatible with consumer-electronics-grade sources and detectors, leading to the possibility of low-cost instrumentation. The nanophotonic sensor chip exhibits a detection limit of 6 × 10 RIU (Refractive Index Units), which is in the same order of magnitude as the reported values for state-of-the-art evanescent wave sensors. The sensor chip is biofunctionalised with specific bioreceptors and integrated into a polymer microfluidic cartridge. The POC instrumentation platform contains optical excitation and read-out sub-systems and dedicated on-board software for real-time analysis of patient samples. To demonstrate the versatility of the platform, we present results both on the detection of an antigen related to tuberculosis directly in urine samples using a laboratory prototype and on the detection of a protein biomarker (CRP) related to inflammation using the integrated instrument. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
17599679 |
| Relation: |
European Commission 610389; Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-624; Ministerio de EconomÃa y Competitividad SEV-2013-0295; Analytical methods; Vol. 10, Issue 25 (July 2018), p. 3066-3073; https://ddd.uab.cat/record/205474; urn:10.1039/c8ay00666k; urn:oai:ddd.uab.cat:205474; urn:scopus_id:85049238791; urn:articleid:17599679v10n25p3066; urn:wos_id:000436816400016; urn:icn2uab:6030702 |
| الاتاحة: |
https://ddd.uab.cat/record/205474 |
| Rights: |
open access ; Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permÃs del(s) titular(s) de drets. ; https://rightsstatements.org/vocab/InC/1.0/ |
| رقم الانضمام: |
edsbas.B84FD3C9 |
| قاعدة البيانات: |
BASE |