Academic Journal
Influence of LRINEC Scoring On Risk Factors and Early Management of Necrotizing Fasciitis, a Prospective Study
| العنوان: | Influence of LRINEC Scoring On Risk Factors and Early Management of Necrotizing Fasciitis, a Prospective Study |
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| المؤلفون: | Inuganti Gopal, Nirodkumar Sahoo, Bibhuprasada Mohapatra, Sumita Tripathy, Debabrata Patra |
| المصدر: | International Journal of Pharmaceutical and Clinical Research, 16(7), 1518-1530, (2024-07-31) |
| بيانات النشر: | International Journal of Pharmaceutical and Clinical Research |
| سنة النشر: | 2024 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Necrotizing Fasciitis, LRINEC Score, Diagnostic Performance, Soft Tissue Infection, Surgical Debridement |
| الوصف: | Background: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with a high mortality rate, necessitating early diagnosis and intervention. The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system, Doppler study, and microbial study aims to early diagnosing and management of NF. Objective: This study aims to assess the diagnostic performance of the LRINEC scoring system with Doppler study and microbial study for early diagnosis and management of NF to prevent morbidity and mortality. Methods: A prospective descriptive study enrolling 99 patients with soft tissue infection admitted to MKCG medical college and hospital, Berhampur, Demographic characteristics and clinical data were collected, and LRINEC scores were calculated based on laboratory parameters, including CRP, WBC count, hemoglobin, sodium, creatinine, and glucose levels. The association between LRINEC scores and NF diagnosis was analyzed, and diagnostic performance metrics such as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated along with Doppler study, microbial flora and management analysed. Results: The majority of participants were aged over 50 years (55.5%) and male (55.5%). The most prevalent comorbidities were diabetes mellitus (25%) and hypertension (30%). Higher LRINEC scores (>=8) were strongly associated with confirmed NF cases, showing high sensitivity (95%), specificity (90%), PPV (85%), and NPV (92%). Culture results identified Klebsiella, Staphylococcus, and E. coli as the most common pathogens, with significant sensitivity to Amikacin. Conclusion: The LRINEC scoring system demonstrates high diagnostic performance in identifying NF cases. Integrating the LRINEC score, with Doppler study, microbial study and multidisciplinary management into clinical practice can improve early diagnosis and intervention, leading to better patient outcomes. Further studies are recommended to validate these findings in diverse patient populations. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.5281/zenodo.13318690; https://doi.org/10.5281/zenodo.13318691; oai:zenodo.org:13318691; https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article256.pdf |
| DOI: | 10.5281/zenodo.13318691 |
| الاتاحة: | https://doi.org/10.5281/zenodo.13318691 https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article256.pdf |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: | edsbas.B83C1155 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.13318691 |
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