Academic Journal
The MCP-3/Ccr3 axis contributes to increased bone mass by affecting osteoblast and osteoclast differentiation
| العنوان: | The MCP-3/Ccr3 axis contributes to increased bone mass by affecting osteoblast and osteoclast differentiation |
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| المؤلفون: | Kim, Jung Ha, Kim, Kabsun, Kim, Inyoung, Seong, Semun, Che, Xiangguo, Choi, Je-Yong, Koh, Jeong-Tae, Kim, Nacksung |
| المساهمون: | National Research Foundation of Korea |
| المصدر: | Experimental & Molecular Medicine ; volume 56, issue 11, page 2465-2474 ; ISSN 2092-6413 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Several CC subfamily chemokines have been reported to regulate bone metabolism by affecting osteoblast or osteoclast differentiation. However, the role of monocyte chemotactic protein 3 (MCP-3), a CC chemokine, in bone remodeling is not well understood. Here, we show that MCP-3 regulates bone remodeling by promoting osteoblast differentiation and inhibiting osteoclast differentiation. In a Ccr3-dependent manner, MCP-3 promoted osteoblast differentiation by stimulating p38 phosphorylation and suppressed osteoclast differentiation by upregulating interferon beta. MCP-3 increased bone morphogenetic protein 2-induced ectopic bone formation, and mice with MCP-3-overexpressing osteoblast precursor cells presented increased bone mass. Moreover, MCP-3 exhibited therapeutic effects by abrogating receptor activator of nuclear factor kappa-B ligand-induced bone loss. Therefore, MCP-3 has therapeutic potential for diseases involving bone loss due to its positive role in osteoblast differentiation and negative role in osteoclast differentiation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s12276-024-01344-6 |
| الاتاحة: | https://doi.org/10.1038/s12276-024-01344-6 https://www.nature.com/articles/s12276-024-01344-6.pdf https://www.nature.com/articles/s12276-024-01344-6 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.B81C88AC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s12276-024-01344-6 |
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