التفاصيل البيبلوغرافية
| العنوان: |
Cluster analysis of adult individuals with type 1 diabetes: treatment pathways and complications over a five-year follow-up period |
| المؤلفون: |
Somolinos Simón, Francisco Javier, García Sáez, Gema, Tapia Galisteo, José, Corcoy, Rosa, Hernando Pérez, María Elena |
| المصدر: |
Diabetes Research and Clinical Practice, ISSN 0168-8227, 2024-09-01, Vol. 215 |
| بيانات النشر: |
E.T.S.I. Telecomunicación (UPM) |
| سنة النشر: |
2024 |
| المجموعة: |
Universidad Politécnica de Madrid: Archivo Digital de la UPM |
| مصطلحات موضوعية: |
Medicina |
| الوصف: |
Aims: To identify subgroups of adults with type 1 diabetes and analyse their treatment pathways and risk of diabetes-related complications over a 5-year follow-up. Methods: We performed a k-means cluster analysis using the T1DExchange Registry (n = 6,302) to identify subgroups based on demographic and clinical characteristics. Annual reassessments linked treatment trajectories with these clusters, considering drug and technology use. Complication risks were analysed using Cox regression. Results: Five clusters were identified: 1) A favourable combination of all variables (31.67 %); 2) Longer diabetes duration (22.63 %); 3) Higher HbA1c levels (13.28 %); 4) Higher BMI (15.25 %); 5) Older age at diagnosis (17.17 %). Two-thirds of patients remained in their initial cluster annually. Technology adoption showed improved glycaemic control over time. Cox proportional hazards showed different risk patterns: Cluster 1 had low complication risk; Cluster 2 had the highest risk for retinopathy, coronary artery disease and autonomic neuropathy; Cluster 3 had the highest risk for albuminuria, depression and diabetic ketoacidosis; Cluster 4 had increased risk for multiple complications; Cluster 5 had the highest risk for hypertension and severe hypoglycaemia, with elevated coronary artery disease risk. Conclusions: Clinical characteristics can identify subgroups of patients with T1DM showing differences in treatment and complications during follow-up. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://www.sciencedirect.com/science/article/pii/S0168822724007137?via%3Dihub; info:eu-repo/grantAgreement/EC/H2020/825162; https://oa.upm.es/84617/ |
| الاتاحة: |
https://oa.upm.es/84617/ |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.B7E8D76F |
| قاعدة البيانات: |
BASE |