Academic Journal
Quantitative Analysis of Total Plasma Homocysteine by LC‐MS/MS
| العنوان: | Quantitative Analysis of Total Plasma Homocysteine by LC‐MS/MS |
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| المؤلفون: | Yuan, Libin, Sharer, J. Daniel |
| المصدر: | Current Protocols in Human Genetics ; volume 89, issue 1 ; ISSN 1934-8266 1934-8258 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Homocysteine is a nonessential, sulfur‐containing amino acid involved in one‐carbon (folate) metabolism. A number of inherited and acquired conditions cause increased accumulation of this metabolite in blood (homocysteinemia) and other biofluids. Homocysteinemia is a risk factor for cardiovascular disease, including recurrent thrombosis. Accurate measurement of total plasma homocysteine is an important element in the diagnostic evaluation of these disorders. While a number of different methods have been developed for this purpose, the focus of this unit will be on a specific technique utilizing liquid chromatography‐tandem mass spectrometry, which provides several advantages in terms of speed, sensitivity, and specificity. © 2016 by John Wiley & Sons, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/0471142905.hg1721s89 |
| الاتاحة: | http://dx.doi.org/10.1002/0471142905.hg1721s89 http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F0471142905.hg1721s89 https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471142905.hg1721s89 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/0471142905.hg1721s89 https://currentprotocols.onlinelibrary.wiley.com/doi/pdf/10.1002/0471142905.hg1721s89 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.B7D1458E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/0471142905.hg1721s89 |
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