Academic Journal
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
| العنوان: | A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer |
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| المؤلفون: | Wu, Yin, Biswas, Dhruva, Usaite, Ieva, Angelova, Mihaela, Boeing, Stefan, Karasaki, Takahiro, Veeriah, Selvaraju, Czyzewska-Khan, Justyna, Morton, Cienne, Joseph, Magdalene, Hessey, Sonya, Reading, James, Georgiou, Andrew, Al-Bakir, Maise |
| المصدر: | Wu , Y , Biswas , D , Usaite , I , Angelova , M , Boeing , S , Karasaki , T , Veeriah , S , Czyzewska-Khan , J , Morton , C , Joseph , M , Hessey , S , Reading , J , Georgiou , A , Al-Bakir , M & TRACERx Consortium 2022 , ' A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer ' , Nature Cancer , vol. 3 , no. 6 , pp. 696-709 . https://doi.org/10.1038/s43018-022-00376-z |
| سنة النشر: | 2022 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Animals, CD8-Positive T-Lymphocytes/metabolism, Carcinoma, Non-Small-Cell Lung/metabolism, Humans, Lung Neoplasms/metabolism, Mice, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocyte Subsets |
| الوصف: | Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8 + T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA − CD27 − effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103 + tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1038/s43018-022-00376-z |
| الاتاحة: | https://pure.au.dk/portal/en/publications/c576aa51-ca99-484f-b18f-8b2b637a0df1 https://doi.org/10.1038/s43018-022-00376-z https://pure.au.dk/ws/files/331556444/s43018_022_00376_z.pdf http://www.scopus.com/inward/record.url?scp=85132983276&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B783F97A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s43018-022-00376-z |
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