Academic Journal
2196. Frequencies of Adenovirus Types in U.S. Children with Acute Respiratory Illness, 2016–2019
| العنوان: | 2196. Frequencies of Adenovirus Types in U.S. Children with Acute Respiratory Illness, 2016–2019 |
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| المؤلفون: | Probst, Varvara, Stopczynski, Tess, Amarin, Justin Z, Spieker, Andrew J, Rahman, Herdi Kurnia, Stewart, Laura S, Selvarangan, Rangaraj, Schuster, Jennifer E, Michaels, Marian G, Williams, John, Boom, Julie A, Sahni, Leila C, Avadhanula, Vasanthi, Staat, Mary A, Schlaudecker, Elizabeth P, McNeal, Monica, Harrison, Christopher J, Moffatt, Mary E, Weinberg, Geoffrey A, Szilagyi, Peter G, Englund, Janet A, Klein, Eileen J, Curns, Aaron T, Perez, Ariana, Clopper, Benjamin R, Rha, Brian, Gerber, Susan I, Chappell, James, Halasa, Natasha B |
| المصدر: | Open Forum Infectious Diseases ; volume 9, issue Supplement_2 ; ISSN 2328-8957 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Infectious Diseases, Oncology |
| الوصف: | Background Adenovirus (AdV) is a common cause of acute respiratory illness (ARI). Multiple respiratory AdV types have been identified in humans, but it remains unclear which are the most common in U.S. children with ARI. Methods We conducted a multicenter, prospective viral surveillance study at seven U.S. children’s hospitals, the New Vaccine Surveillance Network, during 12/1/16–11/30/19, prior to the COVID-19 pandemic. Children < 18 years of age seen in the emergency department or hospitalized with fever and/or respiratory symptoms were enrolled, and mid-turbinate nasal +/- throat swabs were tested using multiplex respiratory pathogen assays or real time polymerase chain reaction (PCR) test for AdV, respiratory syncytial virus (RSV), human metapneumovirus, rhinovirus/enterovirus (RV), influenza, parainfluenza viruses, and endemic coronaviruses. AdV-positive specimens were subsequently typed using single-plex qPCR assays targeting sequences in the hexon gene specific for types 1-7, 11, 14, 16 and 21. Demographics, clinical characteristics, and outcomes were compared between AdV types. Results Of 29,381 enrolled children, 2,106 (7.2%) tested positive for AdV. The distribution of types among the 1,330 (63.2%) successfully typed specimens were as follows: 31.7% AdV-2, 28.9% AdV-1, 15.3% AdV-3, 7.9% AdV-5, 5.9% AdV-7, 1.4% AdV-4, 1.2% AdV-6, 0.5% AdV-14, 0.2% AdV-21, 0.1% AdV-11, and 7.0% ≥1 AdV type. Most children with AdV-1 or AdV-2 detection were < 5 years of age (Figure 1a). Demographic and clinical characteristics varied by AdV types, including age, race/ethnicity, smoke exposure, daycare/school attendance, and hospitalization (Table 1). Co-detection with other viruses was common among all AdV types, with RV and RSV being the most frequently co-detected (Figure 1b). Fever and cough were the most common symptoms for all AdV types (Figure 2). Children with AdV-7 detected as single pathogen had higher odds of hospitalization (adjusted odds ratio 6.34 [95% CI: 3.10, 12.95], p= 0.027). ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ofid/ofac492.1815 |
| الاتاحة: | http://dx.doi.org/10.1093/ofid/ofac492.1815 https://academic.oup.com/ofid/article-pdf/9/Supplement_2/ofac492.1815/47896688/ofac492.1815.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.B7470B7B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ofid/ofac492.1815 |
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