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Krishnendu Manna,1,* Zareen S Khan,2,* Moumita Saha,3,* Snehasis Mishra,3 Nilesh Gaikwad,4 Jatindra Nath Bhakta,1 Kaushik Banerjee,2 Krishna Das Saha3 1Department of Food & Nutrition, University of Kalyani, Nadia, West Bengal, India; 2National Referral Laboratory, ICAR-National Research Centre for Grapes, Pune, Maharashtra, 412307, India; 3Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, 700032, India; 4ICAR-National Research Centre on Pomegranate, Solapur, Maharashtra, 413255, India*These authors contributed equally to this workCorrespondence: Krishna Das Saha, Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, West Bengal, 700032, India, Tel +91 33 2499 5810, Fax +91 33 2473 5197, Email krishna@iicb.res.in Kaushik Banerjee, National Referral Laboratory, ICAR-National Research Centre for Grapes, Pune, Maharashtra, 412307, India, Email kbgrape@yahoo.comObjective: Grape Seed Extract is a natural source of various polyphenols, which have been shown to possess potent antioxidant and free radical-scavenging activities. The earlier studies have reported that grape seed extract exhibits broad-spectrum pharmacological activities. Therefore, studying the hepatoprotective effects and elucidation of mechanisms of action of the Indian Variety, Manjari Medika grape seed extract (GSE), may give an insight into therapeutic benefits. Methotrexate (MTX) is the first-line pharmacological therapy for different rheumatic diseases. The major adverse events such as hepatotoxicity are evident even in the low doses used for the treatment. The present study investigated the role of MTX on hepatic damage in murine liver and the plausible protective effects of the Indian grape variety, Manjari Medika grape seed extract, in ameliorating it.Methods and Results: To assess the hepatological modulation, mice were divided into eight groups to investigate the ameliorative potential of this GSE (75 ... |