Academic Journal
Clinical characteristics of multiple sclerosis in Taiwan: a cross-sectional study
| العنوان: | Clinical characteristics of multiple sclerosis in Taiwan: a cross-sectional study |
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| المؤلفون: | Chang, K H, Lyu, R K, Chen, C M, Hsu, W C, Wu, Y R, Chen, S T, Ro, L S |
| المصدر: | Multiple Sclerosis Journal ; volume 12, issue 4, page 501-506 ; ISSN 1352-4585 1477-0970 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2006 |
| الوصف: | This study reviewed the clinical characteristics of multiple sclerosis (MS) in Taiwanese patients from 1993 to 2001. Of the 75 MS patients with a mean age of onset of 35.6±12.6 years, the female-to-male ratio was 4.4 (61/14). In 42 (56%) optico-spinal MS (OS-MS) patients, the age of onset (37.6±11.1 years) tended to be older than conventional MS (C-MS) patients (33.1±14.1 years, P = 0.08). In 60 cerebrospinal fluid (CSF) specimens, raised IgG index (>0.7) and oligoclonal bands were noted in 26 (43.3%) and two (3.3%) cases, respectively. The frequency of raised IgG index was lower in OSMS (31.3%) than in C-MS (57.1%, P = 0.07). The CSF total protein concentrations were significantly higher in OS-MS (64.5 mg/dL) than in C-MS (46.6 mg/dL, P = 0.047). The mean annual relapse rate was 54.1%, and was significantly higher within the first year (59.7%, P<0.001). The mean annual relapse rate in OS-MS (62.7%) was significantly higher than in C-MS (41.2%, P = 0.01). The differences in the annual relapse rate and total protein concentration in CSF between OS-MS and C-MS suggest probably two distinct immunopathogenesis. The higher first year relapse rate of MS patients in Taiwan may address the importance of early intervention with immunomodulatory therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1191/1352458506ms1297oa |
| الاتاحة: | https://doi.org/10.1191/1352458506ms1297oa https://journals.sagepub.com/doi/pdf/10.1191/1352458506ms1297oa |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.B71E9BBF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1191/1352458506ms1297oa |
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