Academic Journal
An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles
| العنوان: | An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles |
|---|---|
| المؤلفون: | Stander, Barend Andre, Van Vollenstee, Fiona A., Kallmeyer, Karlien, Potgieter, Marnie, Joubert, Annie M., Swanepoel, Andri, Kotze, Lara, Moolman, Sean, Pepper, Michael Sean |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2018 |
| المجموعة: | University of Pretoria: UPSpace |
| مصطلحات موضوعية: | Dermal fillers, Biodegradable polymers, Polycaprolactone (PCL), Mouse embryo fibroblasts (MEF) |
| الوصف: | S1 File. Figure A: Chronic inflammation in the test animals over the trial period. Figure B: Acute inflammation in the test animals over the trial period. Figure C: Tissue necrosis in the test animals over the trial period. Figure D: Fibrosis in the test animals over the trial period. Figure E: Granulomatous/foreign body response in the test animals over the trial period. Figure F: Representative TEMs of skin biopsies of particles group (A) and particles+MEFs group (B) in the in vivo experiment injecting particles+MEFs. Particles could be identified in skin biopsies of both the particles and particles+MEFs groups. The aim of the TEM investigation was to determine if any cells could be detected inside the particles. No cells were present inside the particles in either group. These results reflect the conclusion that was made after the light microscopy study, indicating that cells did not migrate into the ported PCL particles. Bar in A = 5μm and in B = 10μm. ; S2 File. In vitro and in vivo data. Table A: Groups of rats used in the biotoxicity trial. Table B: Observations on mice in the in vivo experiment assessing the effect of ported PCL particles and cells. Table C: Statistical comparisons preformed between the various white blood cell types assessed from blood smears of experimental mice injected with ported PCL particles with or without MEFs. Table D: Schedule of the in vivo experiment assessing the effect of ported and non-ported PCL as well as polystyrene (PS) particles. Table E: Overview of the animals, tests and procedures performed in the in vivo experiment assessing the effect of ported and non-ported PCL as well as polystyrene (PS) particles in BALB/c mice. ; S3 File. All data underlying the findings of the study. ; The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and this makes them an ideal material for dermal filling purposes. Hollow PCL ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/octet-stream; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| Relation: | 1932-6203 (online); http://hdl.handle.net/2263/71521 |
| DOI: | 10.1371/journal.pone.0198248 |
| الاتاحة: | http://hdl.handle.net/2263/71521 https://doi.org/10.1371/journal.pone.0198248 |
| Rights: | © 2018 Stander et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. |
| رقم الانضمام: | edsbas.B6F468CC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0198248 |
|---|