Academic Journal
Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health
| العنوان: | Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health |
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| المؤلفون: | Birkisdóttir, María Björk, Van’t Sant, Lisanne J., Brandt, Renata M.C., Barnhoorn, Sander, Hoeijmakers, Jan H.J., Vermeij, Wilbert P., Jaarsma, Dick |
| المصدر: | Birkisdóttir , M B , Van’t Sant , L J , Brandt , R M C , Barnhoorn , S , Hoeijmakers , J H J , Vermeij , W P & Jaarsma , D 2023 , ' Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health ' , Frontiers in Aging Neuroscience , vol. 14 , 1095801 . https://doi.org/10.3389/fnagi.2022.1095801 |
| سنة النشر: | 2023 |
| الوصف: | Dietary restriction (DR) is a universal anti-aging intervention, which reduces age-related nervous system pathologies and neurological decline. The degree to which the neuroprotective effect of DR operates by attenuating cell intrinsic degradative processes rather than influencing non-cell autonomous factors such as glial and vascular health or systemic inflammatory status is incompletely understood. Following up on our finding that DR has a remarkably large beneficial effect on nervous system pathology in whole-body DNA repair-deficient progeroid mice, we show here that DR also exerts strong neuroprotection in mouse models in which a single neuronal cell type, i.e., cerebellar Purkinje cells, experience genotoxic stress and consequent premature aging-like dysfunction. Purkinje cell specific hypomorphic and knock-out ERCC1 mice on DR retained 40 and 25% more neurons, respectively, with equal protection against P53 activation, and alike results from whole-body ERCC1-deficient mice. Our findings show that DR strongly reduces Purkinje cell death in our Purkinje cell-specific accelerated aging mouse model, indicating that DR protects Purkinje cells from intrinsic DNA-damage-driven neurodegeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3389/fnagi.2022.1095801 |
| الاتاحة: | https://pure.eur.nl/en/publications/b7bf340a-ca84-47c1-93ab-81051c828a6b https://doi.org/10.3389/fnagi.2022.1095801 https://pure.eur.nl/ws/files/86730316/Purkinje_cell_specific_DNA_repair_deficient_mice_reveal_that_dietary_restriction_protects_neurons_by_cell_intrinsic_preservation_of_genomic_health.pdf http://www.scopus.com/inward/record.url?scp=85147414384&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B68C66BF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fnagi.2022.1095801 |
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