Academic Journal
Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams
| العنوان: | Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams |
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| المؤلفون: | Đorđević, Miloš, Fattori, Serena, Petringa, Giada, Ristić Fira, Aleksandra, Petrović, Ivan, Cuttone, Giacomo, Cirrone, G.A. Pablo |
| المصدر: | Physica Medica |
| سنة النشر: | 2024 |
| المجموعة: | VinaR Repository (Vinča Institute of Nuclear Sciences / University of Belgrade) |
| مصطلحات موضوعية: | Carbon ions, CRL-5876, Geant4, Hadrontherapy, HTB-177, Local effect model (LEM), MCF-7, Monte Carlo simulations, Proton beams, Relative biological effectiveness (RBE), Survival fraction |
| الوصف: | Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1120-1797 |
| Relation: | info:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//; European Union's Horizon 2020 [654002 ENSAR2]; Fondo Affari Internazionali (FAI) of INFN-LNS, Italy; MC-INFN (Monte Carlo at INFN) by the Fifth Committee of INFN, Italy; https://vinar.vin.bg.ac.rs/handle/123456789/12241; 2-s2.0-85178603835 |
| DOI: | 10.1016/j.ejmp.2023.103189 |
| الاتاحة: | https://vinar.vin.bg.ac.rs/handle/123456789/12241 https://doi.org/10.1016/j.ejmp.2023.103189 |
| Rights: | restrictedAccess ; ARR |
| رقم الانضمام: | edsbas.B67AE3AF |
| قاعدة البيانات: | BASE |
| تدمد: | 11201797 |
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| DOI: | 10.1016/j.ejmp.2023.103189 |