Academic Journal

Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines

التفاصيل البيبلوغرافية
العنوان: Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines
المؤلفون: Sharma Naveen, Castorena Carlos M, Cartee Gregory D
المصدر: Nutrition & Metabolism, Vol 9, Iss 1, p 90 (2012)
بيانات النشر: BMC
سنة النشر: 2012
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Myonectin, Myostatin, FGF21, Irisin, Insulin resistance, Dietary restriction, Adiponectin, FNDC5, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
الوصف: Calorie restriction (CR; ~60% of ad libitum, AL intake) has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditional endocrine tissues, including skeletal muscle and other tissues, have been discovered to modulate energy metabolism, body composition, and insulin sensitivity. The aim of this study was to characterize the influence of CR by rats on plasma levels of six of these newly recognized metabolic hormones (BDNF, FGF21, IL-1β, myonectin, myostatin, and irisin). Body composition of 9-month old male Fischer-344/Brown Norway rats (AL and CR groups) was determined by nuclear magnetic resonance. Blood sampled from the carotid artery of unanesthetized rats was used to measure concentrations of glucose and plasma proteins. As expected, CR versus AL rats had significantly altered body composition (reduced percent fat mass, increased percent lean mass) and significantly improved insulin sensitivity (based on the homeostasis model assessment-estimated insulin resistance index). Also consistent with previous reports, CR compared to AL rats had significantly greater plasma levels of adiponectin and corticosterone. However, there were no significant diet-related differences in plasma levels of BDNF, FGF21, IL-1β, myonectin, myostatin, or irisin. In conclusion, these results indicate that alterations in plasma concentration of these six secreted proteins are not essential for the CR-related improvement in insulin sensitivity in rats.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1743-7075
Relation: http://www.nutritionandmetabolism.com/content/9/1/90; https://doaj.org/toc/1743-7075; https://doaj.org/article/699856ca1e5f45338542b114dbace159
DOI: 10.1186/1743-7075-9-90
الاتاحة: https://doi.org/10.1186/1743-7075-9-90
https://doaj.org/article/699856ca1e5f45338542b114dbace159
رقم الانضمام: edsbas.B638EE7D
قاعدة البيانات: BASE
الوصف
تدمد:17437075
DOI:10.1186/1743-7075-9-90