Academic Journal
Mechanisms of VIP-induced neuroprotection against neonatal excitotoxicity. : MECHANISMS OF VIP-INDUCED NEUROPROTECTION
| العنوان: | Mechanisms of VIP-induced neuroprotection against neonatal excitotoxicity. : MECHANISMS OF VIP-INDUCED NEUROPROTECTION |
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| المؤلفون: | Rangon, Claire-Marie, Dicou, Eleni, Goursaud, Stéphanie, Mounien, Lourdes, Jégou, Sylvie, Janet, Thierry, Muller, Jean-Marc, Lelièvre, Vincent, Gressens, Pierre |
| المساهمون: | UCL - Autre |
| المصدر: | Annals of the New York Academy of Sciences, Vol. 1070, p. 512-7 (2006) |
| سنة النشر: | 2006 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| مصطلحات موضوعية: | Animals, Newborn, Vasoactive Intestinal Peptide - pharmacology, Brain - drug effects, Brain-Derived Neurotrophic Factor - genetics, Mice, Neurons - drug effects, metabolism, Neuroprotective Agents - pharmacology, Neurotoxins - pharmacology, Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology, Receptors, Vasoactive Intestinal Peptide, Type II - metabolism, VPAC2, PACAP, PKC, BDNF, PHI |
| الوصف: | Two VIP receptors, shared with a similar affinity by pituitary adenylate cyclase-activating polypeptide (PACAP), have been cloned: VPAC1 and VPAC2. PHI binds to these receptors with a lower affinity. We previously showed that VIP protects against excitotoxic white matter damage in newborn mice. This article aimed to determine the receptor involved in VIP-induced neuroprotection. VIP effects were mimicked with a similar potency by VPAC2 agonists and PHI but not by VPAC1 agonists, PACAP 27 or PACAP 38. VIP neuroprotective effects were lost in mice lacking VPAC2 receptor. In situ hybridization confirmed the presence of VPAC2 mRNA. These data suggest that, in this model, VIP-induced neuroprotection is mediated by VPAC2 receptors. The pharmacology of this VPAC2 receptor seems unconventional as PACAP does not mimic VIP effects and PHI acts with a comparable potency. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0077-8923 |
| Relation: | boreal:106531; http://hdl.handle.net/2078.1/106531; info:pmid/16888217; urn:ISSN:0077-8923 |
| DOI: | 10.1196/annals.1317.071 |
| الاتاحة: | http://hdl.handle.net/2078.1/106531 https://doi.org/10.1196/annals.1317.071 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B622E6D2 |
| قاعدة البيانات: | BASE |
| تدمد: | 00778923 |
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| DOI: | 10.1196/annals.1317.071 |