Academic Journal
Intranasal Flunisolide Treatment in Children with Adenoidal Hypertrophy
| العنوان: | Intranasal Flunisolide Treatment in Children with Adenoidal Hypertrophy |
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| المؤلفون: | Ciprandi, G., Varricchio, A., Capasso, M., Varricchio, A.M., De Lucia, A., Ascione, E., Avvisati, F., Capristo, C., Marseglia, G.L., Barillari, U. |
| المصدر: | International Journal of Immunopathology and Pharmacology ; volume 20, issue 4, page 833-836 ; ISSN 0394-6320 2058-7384 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2007 |
| الوصف: | Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children and it has been proposed that treatment with intranasal corticosteroids can decrease the size of AH. Therefore, the aim of the study is to evaluate the effect of the use of intranasal flunisolide among children affected by AH. 178 children with AH were evaluated in this randomised and controlled study. Inclusion criteria for the study required that each patient had to have a HI or IV degree of AH on the initial endoscopic examination. Children were treated with intranasal flunisolide or isotonic saline solution for 8 weeks. After treatment, endoscopy was performed to re-evaluate AH degree. Flunisolide treatment was associated with significant (p<0.04) reduction of AH degree. There was moreover a consistent reduction of children (46 out of 58) proposed to adenoidectomy. No clinically important adverse events were reported. In conclusion, this preliminary study demonstrates that an 8-week treatment with intranasal flunisolide is significantly associated with reduction of AH, thus preventing the recurrence to adenoidectomy, and is safe. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/039463200702000420 |
| الاتاحة: | https://doi.org/10.1177/039463200702000420 https://journals.sagepub.com/doi/pdf/10.1177/039463200702000420 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license ; http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.B61C5BA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/039463200702000420 |
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