Academic Journal
Carbon tetrachloride-induced nephrotoxicity and DNA damage in rats ; Protective role of vanillin
| العنوان: | Carbon tetrachloride-induced nephrotoxicity and DNA damage in rats ; Protective role of vanillin |
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| المؤلفون: | Makni, M, Chtourou, Y, Garoui, EM, Boudawara, T, Fetoui, H |
| المصدر: | Human & Experimental Toxicology ; volume 31, issue 8, page 844-852 ; ISSN 0960-3271 1477-0903 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2012 |
| الوصف: | In this study, the protective effects of vanillin were evaluated against carbon tetrachloride (CCl 4 )-induced kidney damages in Wistar albino rats. CCl 4 (1 ml/kg, intraperitoneally [i.p.]) caused a significant induction of renal disorder, oxidative damage and DNA fragmentation as evidenced by increased plasma creatinine, urea and uric acid levels, increased lipid peroxidation (malondialdehyde [MDA]) and protein carbonyl. Furthermore, glutathione levels, catalase, superoxide dismutase, glutathione transferase and glutathione peroxidase activities were significantly decreased. A smear without ladder formation on agarose gel was also shown, indicating random DNA degradation. Pretreatment of rats with vanillin (150 mg/kg/day, i.p.), for 3 consecutive days before CCl 4 injection, protected kidney against the increase of MDA and degradation of membrane proteins compared to CCl 4 -treated rats and exhibited marked prevention against CCl 4 -induced nephropathology, oxidative stress and DNA damage. Kidney histological sections showed glomerular hypertrophy and tubular dilatation in CCl 4 -treated rats, however, in vanillin pretreated rats, these histopathological changes were less important and present a similar structure to that of control rats. These data indicated the protective role of vanillin against CCl 4 -induced nephrotoxicity and suggested its significant contribution of these beneficial effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0960327111429140 |
| الاتاحة: | https://doi.org/10.1177/0960327111429140 https://journals.sagepub.com/doi/pdf/10.1177/0960327111429140 https://journals.sagepub.com/doi/full-xml/10.1177/0960327111429140 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.B5F4265 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0960327111429140 |
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