التفاصيل البيبلوغرافية
| العنوان: |
Natural Resistance to HIV-1: A Systematic Review ; Resistencia natural a la infección por el VIH-1. Revisión sistemática de la literatura |
| المؤلفون: |
Alarcón-Uribe, Santiago, Zapata-Builes, Wildeman, Higuita-Gutiérrez, Luis Felipe |
| المصدر: |
Iatreia; Vol. 37 No. 1 (2024) ; Iatreia; Vol. 37 Núm. 1 (2024) ; 2011-7965 ; 0121-0793 |
| بيانات النشر: |
Universidad de Antioquia |
| سنة النشر: |
2023 |
| المجموعة: |
Universidad de Antioquia: Sistema de Revistas |
| مصطلحات موضوعية: |
Inmunidad Innata, VIH-1, Revisión Sistemática, Immunity Innate, HIV1, Systematic Review |
| جغرافية الموضوع: |
Latin America, Iberoamérica |
| الوصف: |
Introduction: Research on HIV-1 infection has led to the identification of individuals who, despite repeated exposure to the virus, show no signs of infection. These individuals are termed as HIV-exposed seronegative (HESN), indicating potential mechanisms of natural resistance to HIV-1. Objective: To outline the available literature on HESN individuals and their mechanisms of natural resistance. Methods: A comprehensive systematic literature review was conducted across six databases, adhering to the PRISMA guidelines. Data analysis involved absolute and relative frequencies, as well as a scientific collaboration network analysis using Ghepi. Results: 124 articles were found, encompassing 4,079 HESN individuals. The scientific community focused on this topic comprised 688 researchers from the United States, Italy, Canada, Spain, Brazil, and Colombia. The criteria for designating an individual as HESN were highly variable. 33 distinct mechanisms associated with natural resistance to HIV-1 were identified. The most prevalent were soluble factors in mucosal and peripheral blood (30.6%), followed by the Δ32 mutation (14.5%), KIR/HLA alleles (10.5%), and neutralizing IgA (10.5%). Conclusions: A solid scientific community is actively exploring natural resistance to HIV-1 infection. There is notable diversity in the immunological mechanisms involved in natural virus resistance and significant variability in the criteria defining HESN populations. ; Introducción: la investigación sobre la infección por VIH-1 ha permitido identificar individuos que, a pesar de exponerse en múltiples ocasiones al virus, no presentan signos de infección. Se conocen como expuestos a VIH seronegativos o HESN (del inglés HIV-exposed seronegative). Esto sugiere la existencia de mecanismos de resistencia natural al VIH-1. Objetivo: describir la información disponible en la literatura sobre los HESN y sus mecanismos de resistencia natural. Métodos: se realizó una revisión sistemática de la literatura de enfoque amplio en seis bases de datos y se ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
Spanish; Castilian |
| Relation: |
https://revistas.udea.edu.co/index.php/iatreia/article/view/349513/20815962; https://revistas.udea.edu.co/index.php/iatreia/article/view/349513/20810865; https://revistas.udea.edu.co/index.php/iatreia/article/view/349513 |
| الاتاحة: |
https://revistas.udea.edu.co/index.php/iatreia/article/view/349513 |
| Rights: |
Derechos de autor 2023 Iatreia ; https://creativecommons.org/licenses/by-sa/4.0 |
| رقم الانضمام: |
edsbas.B5E9B4E7 |
| قاعدة البيانات: |
BASE |