Academic Journal
Indole-based alkaloids from deep-sea bacterium Shewanella piezotolerans with antitumor activities
| العنوان: | Indole-based alkaloids from deep-sea bacterium Shewanella piezotolerans with antitumor activities |
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| المؤلفون: | Wang, Yao, Tang, Xixiang, Shao, Zhongzhe, Ren, Jinwei, Liu, Dong, Proksch, Peter, Lin, Wenhan |
| المساهمون: | Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drug, Xueyuan Rd 38, Beijing 100191, Peoples R China., Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100191, Peoples R China., State Ocean Adm, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen, Peoples R China., Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Dusseldorf, Germany., Peking Univ, State Key Lab Nat & Biomimet Drug, Xueyuan Rd 38, Beijing 100191, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | journal of antibiotics |
| سنة النشر: | 2014 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | bacterium, chromatographic separation, cytotoxic evaluation, indole alkaloid, Shewanella piezotolerans, shewanellines A-C, structural elucidation, NATURAL-PRODUCTS, WEST PACIFIC, ISATINS |
| الوصف: | Chromatographic separation of a crude extract obtained from a fermentation broth of a chemically unknown bacterium Shewanella piezotolerans WP3 collected in deep-sea yielded three new indole alkaloids namely shewanellines A (1a), B (1b) and C (2), together with 12 known indole alkaloids. The structures were unambiguously elucidated on the basis of 1D and 2D NMR (H-1, C-13, COSY, HMBC, HSQC and NOESY) in association with MS and CD data. Compounds 1-4, 7, 9 and 11-14 were selected for the evaluation of their cytotoxic activities against human tumor cell lines HL-60 and BEL-7402, whereas compounds 2, 4 and 9 exhibited significant inhibition toward HL-60. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337017100008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy ; SCI(E) ; PubMed ; 7 ; ARTICLE ; whlin@bjmu.edu.cn ; 5 ; 395-399 ; 67 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0021-8820 |
| Relation: | JOURNAL OF ANTIBIOTICS.2014,67,(5),395-399.; 655790; http://hdl.handle.net/20.500.11897/342714; WOS:000337017100008 |
| DOI: | 10.1038/ja.2014.3 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/342714 https://doi.org/10.1038/ja.2014.3 |
| رقم الانضمام: | edsbas.B5C4FDC5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00218820 |
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| DOI: | 10.1038/ja.2014.3 |