التفاصيل البيبلوغرافية
| العنوان: |
Echinocystic Acid Bidesmoside Saponins from Microglossa afzelii O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line |
| المؤلفون: |
Billy Toussie Tchegnitegni, Tehmina Ahmed, Francis Tatong Ngouafong, Viviane Flore Kamlo Kamso, Rémy Bertrand Teponno, Bruno Ndjakou Lenta, Léon Azefack Tapondjou, Arslan Ali, Syed Ghulam Musharraf |
| المصدر: |
Metabolites; Volume 12; Issue 11; Pages: 1018 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Microglossa afzelii, asteraceae, triterpenoid saponins, cytotoxic activity |
| الوصف: |
This paper describes eight new triterpenoid saponins, including afzeliioside A (1), four acetylated afzeliiosides as pairs of inseparable regioisomers, called afzeliiosides B/C (2/3) and D/E (4/5), afzeliiosides F-H (6–8), and a known impatiprin C (9), which were isolated from the n-BuOH fraction of the liana of Microglossa afzelii. Their structures were established mainly by extensive spectroscopic analysis, including 1D and 2D NMR, HRFAB-MS, tandem ESI-MS/MS, and chemical methods, as well as a comparison of their spectral data with those of related compounds. All the isolates were screened for their cytotoxic activity against the CAL-27 oral squamous carcinoma cell line. Only compounds 4/5 (EC50 = 36.0 μg/mL (32.7 μM)) exhibited moderate cytotoxic activity. This work presents the first chemical and biological investigation of Microglossa afzelii and reports, for the first time, on the isolation of saponins in the genus Microglossa. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Plant Metabolism; https://dx.doi.org/10.3390/metabo12111018 |
| DOI: |
10.3390/metabo12111018 |
| الاتاحة: |
https://doi.org/10.3390/metabo12111018 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.B55F08C9 |
| قاعدة البيانات: |
BASE |