Academic Journal
The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control
| العنوان: | The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control |
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| المؤلفون: | Jaadane, Imene, Chahory, Sabine, Leprêtre, Chloé, Omri, Boubaker, Jonet, Laurent, Behar-Cohen, Francine, Crisanti, Patricia, Torriglia, Alicia |
| المساهمون: | Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), École nationale vétérinaire d'Alfort (ENVA), Jules Gonin Eye Hospital |
| المصدر: | ISSN: 1582-1838. |
| بيانات النشر: | HAL CCSD Wiley Open Access |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | PKC zeta, serpin B1, retinal apoptosis, retinal degeneration, light, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspase-independent apop-totic pathway, is responsible for photoreceptor death. In this work, we investigated the activation of a pro-survival kinase, the protein kinase C (PKC) zeta. We show that light exposure induced PKC zeta activation. PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation. These results highlight the role of PKC zeta in retinal physiology and show that this kinase can control caspase-independent pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-01271030; https://hal.sorbonne-universite.fr/hal-01271030; https://hal.sorbonne-universite.fr/hal-01271030/document; https://hal.sorbonne-universite.fr/hal-01271030/file/jcmm12539.pdf |
| DOI: | 10.1111/jcmm.12539 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-01271030 https://hal.sorbonne-universite.fr/hal-01271030/document https://hal.sorbonne-universite.fr/hal-01271030/file/jcmm12539.pdf https://doi.org/10.1111/jcmm.12539 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B54EF568 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jcmm.12539 |
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