Academic Journal
Mpox:Clinical Outcomes and Impact of Vaccination in People with and without HIV: A Population-Wide Study
| العنوان: | Mpox:Clinical Outcomes and Impact of Vaccination in People with and without HIV: A Population-Wide Study |
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| المؤلفون: | Martín-Iguacel, Raquel, Pericas, Carles, Bruguera, Andreu, Rosell, Gemma, Martínez, Erica, Díaz, Yesika, Alonso, Lucia, Nomah, Daniel Kwakye, Blanco, Jose Luis, Domingo, Pere, Álvarez-López, Patricia, Linares, Maria Saumoy, Vilades Laborda, Consuelo, Mera, Arantxa, Calzado Isbert, Sonia, Johansen, Isik Somuncu, Miró, José M., Casabona, Jordi, Llibre, Josep M. |
| المصدر: | Martín-Iguacel , R , Pericas , C , Bruguera , A , Rosell , G , Martínez , E , Díaz , Y , Alonso , L , Nomah , D K , Blanco , J L , Domingo , P , Álvarez-López , P , Linares , M S , Vilades Laborda , C , Mera , A , Calzado Isbert , S , Johansen , I S , Miró , J M , Casabona , J , Llibre , J M & PISCIS Study Group 2023 , ' Mpox : Clinical Outcomes and Impact of Vaccination in .... |
| سنة النشر: | 2023 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | HIV, immunosuppression, mpox, sexually transmitted infections |
| الوصف: | We investigated differences in mpox clinical outcomes in people with HIV (PWH) and without HIV (PWoH) and the impact of vaccination in Catalonia, Spain. We used surveillance data and the PISCIS HIV cohort. We included all confirmed mpox cases (May–December 2022). Of 2122 mpox cases, the majority had mild disease, 56% were Spanish, and 24% were from Latin America. A total of 40% were PWH, with a median CD4+T-cell of 715 cells/μL; 83% had HIV-RNA < 50 copies/mL; and 1.8% CD4+T-cell < 200 cells/μL. PWH had no increased risk for complications, except those with CD4+T-cell < 200 cells/μL. PWH with CD4+T-cell < 200 cells/μL were more likely to be from Latin America, had more generalized exanthema, and required hospitalization more frequently (p = 0.001). Diagnosis of other sexually transmitted infections (STIs) was common, both at mpox diagnosis (17%) and two years before (43%). Dose-sparing smallpox intradermal vaccination was accompanied by a sharp decrease in mpox incidence in both populations (p < 0.0001). In conclusion, unless immunosuppressed, PWH were not at increased risk of severe disease or hospitalization. Mpox is a marker of high-risk sexual behavior and was associated with high HIV and STI rates, supporting the need for screening in all mpox cases. Ethnicity disparities demonstrate the need for interventions to ensure equitable healthcare access. Dose-sparing smallpox vaccination retained effectiveness. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://portal.findresearcher.sdu.dk/da/publications/ee60b744-bcee-4ba5-8b3d-7ff5bfb9db5c |
| DOI: | 10.3390/microorganisms11112701 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/ee60b744-bcee-4ba5-8b3d-7ff5bfb9db5c https://doi.org/10.3390/microorganisms11112701 https://findresearcher.sdu.dk/ws/files/250833800/microorganisms-11-02701-v2.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B543639B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms11112701 |
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