Academic Journal
2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells
| العنوان: | 2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells |
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| المؤلفون: | Asik, Elif, Aslan, Tugba Nur, Volkan, Mürvet, Güray, Nülüfer Tülün |
| بيانات النشر: | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 2-Amino-2-deoxy-glucose, Cobalt ferrite nanoparticles, Breast cancer, Targeting therapy |
| الوصف: | In this study, 2-amino-2-deoxy-glucose (2DG) was conjugated to COOH modified cobalt ferrite magnetic nanoparticles (COOH-MNPs), which were designed to target tumor cells as a potential targetable drug/gene delivery agent for cancer treatment. According to our results, it is apparent that, 2DG labeled MNPs were internalized more efficiently than COOH-MNPs under the same conditions in all cell types (MDA-MB-231 and MCF-7 cancer and MCF-10A normal breast cells) (p < 0.001). Moreover, the highest amount of uptake was observed in MDA-MB-231, followed by MCF-7 and normal MCF-10A cells for both MNPs. The apoptotic effects of 2DG-MNPs were further evaluated, and it was found that apoptosis was not induced at low concentrations of 2DG-MNPs in all cell types, whereas dramatic cell death was observed at higher concentrations. In addition, the gene expression levels of four drug-metabolizing enzymes, two Phase I (CYP1A1, CYP1B1) and two Phase II (GSTM3, GSTZ1) were also increased with the high concentrations of 2DG-MNPs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1382-6689 |
| Relation: | Asik E., Aslan T. N. , VOLKAN M., GÜRAY N. T. , "2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells", ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.41, ss.272-278, 2016; 278; 84952910980; 272; https://hdl.handle.net/11511/49106; 41; WOS:000370094500036 |
| DOI: | 10.1016/j.etap.2015.12.004 |
| الاتاحة: | https://hdl.handle.net/11511/49106 https://doi.org/10.1016/j.etap.2015.12.004 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.B5345F87 |
| قاعدة البيانات: | BASE |
| تدمد: | 13826689 |
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| DOI: | 10.1016/j.etap.2015.12.004 |