Academic Journal
Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1
| العنوان: | Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1 |
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| المؤلفون: | Georg, J, Kostova, G, Vuorijoki, L, Schön, V, Kadowaki, T, Huokko, T, Baumgartner, D, Müller, M, Klähn, S, Allahverdiyeva, Y, Hihara, Y, Futschik, ME, Aro, E-M, Hess, WR |
| بيانات النشر: | Elsevier BV England |
| سنة النشر: | 2017 |
| المجموعة: | PEARL (Plymouth Electronic Archiv & ResearchLibrary, Plymouth University) |
| مصطلحات موضوعية: | Fe/S cluster biogenesis, Synechocystis, cytochrome b(6)f complex, electron transfer, ferredoxin I, iron homeostasis, photosynthesis, regulatory sRNA, Acclimatization, Bacterial Proteins, Cyanobacteria, Gene Expression Profiling, Homeostasis, Iron Deficiencies, Iron-Sulfur Proteins, Oxygen, RNA, Bacterial, Small Untranslated, Transcription, Genetic, Transcriptome |
| الوصف: | Oxygenic photosynthesis crucially depends on proteins that possess Fe2+ or Fe/S complexes as co-factors or prosthetic groups. Here, we show that the small regulatory RNA (sRNA) IsaR1 (Iron-Stress-Activated RNA 1) plays a pivotal role in acclimation to low-iron conditions. The IsaR1 regulon consists of more than 15 direct targets, including Fe2+-containing proteins involved in photosynthetic electron transfer, detoxification of anion radicals, citrate cycle, and tetrapyrrole biogenesis. IsaR1 is essential for maintaining physiological levels of Fe/S cluster biogenesis proteins during iron deprivation. Consequently, IsaR1 affects the acclimation of the photosynthetic apparatus to iron starvation at three levels: (1) directly, via posttranscriptional repression of gene expression; (2) indirectly, via suppression of pigment; and (3) Fe/S cluster biosynthesis. Homologs of IsaR1 are widely conserved throughout the cyanobacterial phylum. We conclude that IsaR1 is a critically important riboregulator. These findings provide a new perspective for understanding the regulation of iron homeostasis in photosynthetic organisms. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1425-1436.e7; Print-Electronic; application/pdf |
| اللغة: | English |
| تدمد: | 0960-9822 1879-0445 |
| Relation: | E-ISSN:1879-0445; http://hdl.handle.net/10026.1/9292 |
| DOI: | 10.1016/j.cub.2017.04.010 |
| الاتاحة: | http://hdl.handle.net/10026.1/9292 https://doi.org/10.1016/j.cub.2017.04.010 |
| رقم الانضمام: | edsbas.B50370DD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09609822 18790445 |
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| DOI: | 10.1016/j.cub.2017.04.010 |