Academic Journal
Synthetic Biology Tools for Engineering Microbial Cells to Fight Superbugs
| العنوان: | Synthetic Biology Tools for Engineering Microbial Cells to Fight Superbugs |
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| المؤلفون: | Angel León-Buitimea, Francisco de Jesús Balderas-Cisneros, César Rodolfo Garza-Cárdenas, Javier Alberto Garza-Cervantes, José Rubén Morones-Ramírez |
| المصدر: | Frontiers in Bioengineering and Biotechnology, Vol 10 (2022) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | synthetic biology, antimicrobial resistance, genetic circuits, antibiotics, phages, whole-cell engineering, Biotechnology, TP248.13-248.65 |
| الوصف: | With the increase in clinical cases of bacterial infections with multiple antibiotic resistance, the world has entered a health crisis. Overuse, inappropriate prescribing, and lack of innovation of antibiotics have contributed to the surge of microorganisms that can overcome traditional antimicrobial treatments. In 2017, the World Health Organization published a list of pathogenic bacteria, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli (ESKAPE). These bacteria can adapt to multiple antibiotics and transfer their resistance to other organisms; therefore, studies to find new therapeutic strategies are needed. One of these strategies is synthetic biology geared toward developing new antimicrobial therapies. Synthetic biology is founded on a solid and well-established theoretical framework that provides tools for conceptualizing, designing, and constructing synthetic biological systems. Recent developments in synthetic biology provide tools for engineering synthetic control systems in microbial cells. Applying protein engineering, DNA synthesis, and in silico design allows building metabolic pathways and biological circuits to control cellular behavior. Thus, synthetic biology advances have permitted the construction of communication systems between microorganisms where exogenous molecules can control specific population behaviors, induce intracellular signaling, and establish co-dependent networks of microorganisms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2296-4185 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.869206/full; https://doaj.org/toc/2296-4185; https://doaj.org/article/cbec9ba0fb5241ba8590fd851c24855b |
| DOI: | 10.3389/fbioe.2022.869206 |
| الاتاحة: | https://doi.org/10.3389/fbioe.2022.869206 https://doaj.org/article/cbec9ba0fb5241ba8590fd851c24855b |
| رقم الانضمام: | edsbas.B4F8E989 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22964185 |
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| DOI: | 10.3389/fbioe.2022.869206 |