Academic Journal
Non-flow limiting non-culprit plaque characteristics in patients presenting with STEMI versus NSTEMI
| العنوان: | Non-flow limiting non-culprit plaque characteristics in patients presenting with STEMI versus NSTEMI |
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| المؤلفون: | Volleberg, R H J A, Mol, J H Q, Meuwissen, M, Protopopov, A V, Laanmets, P, Kresyaninov, O V, Dennert, R, Oemrawsingh, R M, Van Kuijk, J P, Arkenbout, K, Van Der Heijden, D J, Rasoul, S, Van Leeuwen, M A H, Van Geuns, R J M, Van Royen, N |
| المصدر: | European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Background Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) are often considered distinct clinical entities. Although differences in culprit plaque characteristics have been described extensively, less is known about differences in non-culprit (NC) plaque characteristics. Purpose To compare plaque characteristics of fractional flow reserve (FFR)-negative NC lesions as assessed by optical coherence tomography (OCT) in STEMI and NSTEMI patients. Methods PECTUS-obs is a prospective, observational study in which 438 patients presenting with STEMI or NSTEMI underwent OCT of any intermediate FFR-negative NC lesion (defined as a FFR >0.80) after treatment of the infarct related artery. Quantitative and qualitative OCT analyses were performed by an independent core laboratory. A high risk plaque (HRP) was defined as the presence of ≥2 of the following prespecified criteria: 1) a lipid arc ≥90°, 2) a minimal fibrous cap thickness <65 µm, or 3) either cap rupture or thrombus presence. In the present sub-analysis, lesion-level plaque characteristics were compared between patients presenting with STEMI versus NSTEMI while accounting for within-patient clustering and correcting for prespecified clinical variables (age, history of myocardial infarction, diabetes, and estimated glomerular filtration rate (eGFR)). Results Among 420 patients with at least one analyzable OCT, 217 (51.7%) presented with STEMI and 203 (48.3%) with NSTEMI. Patients with STEMI were younger (mean age 62±10 vs 65±11 years, p=0.004) and less frequently had diabetes (11.1% vs 18.2%, p=0.037) and hypercholesterolemia (31.8% vs 41.6%, p=0.038). Baseline mean eGFR (84±19 vs 75±19 ml/min, p<0.001) and low density lipoprotein-cholesterol levels (3.2±1.2 vs 2.9±1.2, p=0.010) were higher in STEMI patients with fewer of these patients using lipid lowering therapy (18.9% vs 33.0%, p<0.001) before enrollment. A total of 494 NC lesions were analyzed, which were equally distributed in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/eurheartj/ehad655.1467 |
| الاتاحة: | https://doi.org/10.1093/eurheartj/ehad655.1467 https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.1467/53594249/ehad655.1467.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.B4D72E5F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehad655.1467 |
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