Academic Journal
An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat
| العنوان: | An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat |
|---|---|
| المؤلفون: | Whitney S. Powell, Juan M. Dominguez, Elaine M. Hull |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.elaine-m-hull.com/publications/NMDA_antagonist.pdf. |
| سنة النشر: | 2003 |
| المجموعة: | CiteSeerX |
| الوصف: | Sexual experience facilitates subsequent male sexual behavior; activation of the N-methyl-D-aspartate (NMDA) glutamate receptor may play a role in this experience-induced enhancement. In this article, the authors report that systemic injections of MK-801, an NMDA receptor antagonist, impaired male sexual behavior in sexually naive and sexually experienced male rats. Furthermore, saline-treated rats that received 7 daily exposures to an inaccessible estrous female instead of sexual experience displayed enhancement of copulation on the following day. Injections of MK-801 before each of these exposures inhibited the experience-induced enhancement on the drug-free test on Day 8. These data suggest that stimulation of NMDA receptors enhances sexual performance immediately and mediates the experienceinduced enhancement of subsequent copulatory behavior. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.7201; http://www.elaine-m-hull.com/publications/NMDA_antagonist.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.7201 http://www.elaine-m-hull.com/publications/NMDA_antagonist.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.B4BF88D2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |