Academic Journal
Metabolic specialization in itaconic acid production: a tale of two fungi
| العنوان: | Metabolic specialization in itaconic acid production: a tale of two fungi |
|---|---|
| المؤلفون: | Wierckx, Nick, Agrimi, Gennaro, Lübeck, Peter Stephensen, Steiger, Matthias G., Mira, Nuno Pereira, Punt, Peter J. |
| المصدر: | Current opinion in biotechnology 62, 153 - 159 (2020). doi:10.1016/j.copbio.2019.09.014 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2020 |
| المجموعة: | Forschungszentrum Jülich: JuSER (Juelich Shared Electronic Resources) |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610 |
| جغرافية الموضوع: | DE |
| الوصف: | Some of the oldest and most established industrial biotechnology processes involve the fungal production of organic acids. In these fungi, the transport of metabolites between cellular compartments, and their secretion, is a major factor. In this review we exemplify the importance of both mitochondrial and plasma membrane transporters in the case of itaconic acid production in two very different fungal systems, Aspergillus and Ustilago. Homologous and heterologous overexpression of both types of transporters, and biochemical analysis of mitochondrial transporter function, show that these two fungi produce the same compound through very different pathways. The way these fungi respond to itaconate stress, especially at low pH, also differs, although this is still an open field which clearly needs additional research. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/issn/0958-1669; info:eu-repo/semantics/altIdentifier/pmid/pmid:31689647; info:eu-repo/semantics/altIdentifier/wos/WOS:000530659900022; info:eu-repo/semantics/altIdentifier/hdl/2128/23446; info:eu-repo/semantics/altIdentifier/issn/1879-0429; https://juser.fz-juelich.de/record/866697; https://juser.fz-juelich.de/search?p=id:%22FZJ-2019-05772%22 |
| الاتاحة: | https://juser.fz-juelich.de/record/866697 https://juser.fz-juelich.de/search?p=id:%22FZJ-2019-05772%22 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B4B0B5AC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |