Academic Journal
Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus
| العنوان: | Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus |
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| المؤلفون: | Kubota, Marie, Matsuoka, Rei, Suzuki, Tateki, Yonekura, Koji, Yanagi, Yusuke, Hashiguchi, Takao |
| المساهمون: | Dutch, Rebecca Ellis, Takeda Science Foundation, Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, MEXT | Japan Society for the Promotion of Science, Terumo Foundation for Life Sciences and Arts |
| المصدر: | Journal of Virology ; volume 93, issue 15 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2019 |
| الوصف: | Mumps virus (MuV) infection is characterized by parotid gland swelling and can cause pancreatitis, orchitis, meningitis, and encephalitis. MuV-related hearing loss is also a serious complication because it is usually irreversible. MuV outbreaks have been reported in many countries, even in high-vaccine-coverage areas. MuV has tropism toward glandular tissues and the central nervous system. To understand the unique MuV tropism, revealing the mechanism of receptor recognition by MuV is very important. Here, using a large-scale glycan array and X-ray crystallography, we show that MuV recognizes sialyl Lewis X and GM2 ganglioside as receptors, in addition to a previously reported MuV receptor, a trisaccharide containing an α2,3-linked sialic acid. The flexible recognition of these glycan receptors by MuV may explain the unique tropism and pathogenesis of MuV. Structures will also provide a template for the development of effective entry inhibitors targeting the receptor-binding site of MuV. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.00344-19 |
| DOI: | 10.1128/JVI.00344-19 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.00344-19 https://journals.asm.org/doi/pdf/10.1128/JVI.00344-19 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.B4750833 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jvi.00344-19 |
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