Academic Journal
ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study
| العنوان: | ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study |
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| المؤلفون: | Yin, Shan, Gao, Pei-Yang, Ou, Ya-Nan, Fu, Yan, Liu, Ying, Wang, Zuo-Teng, Han, Bao-Lin, Tan, Lan |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Alzheimer's Research & Therapy ; volume 16, issue 1 ; ISSN 1758-9193 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Background It has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adults, the correlations of ANU-ADRI scores with cerebrospinal fluid (CSF) core biomarkers and cognition remain unclear. Methods Individuals from the Chinese Alzheimer’s Biomarker and LifestyLE (CABLE) study were grouped into three groups (low/intermediate/high risk groups) based on their ANU-ADRI scores. The multiple linear regression models were conducted to investigate the correlations of ANU-ADRI scores with several biomarkers of AD pathology. Mediation model and structural equation model (SEM) were conducted to investigate the mediators of the correlation between ANU-ADRI scores and cognition. Results A total of 1078 non-demented elders were included in our study, with a mean age of 62.58 (standard deviation [SD] 10.06) years as well as a female proportion of 44.16% (n = 476). ANU-ADRI scores were found to be significantly related with MMSE (β = -0.264, P < 0.001) and MoCA (β = -0.393, P < 0.001), as well as CSF t-tau (β = 0.236, P < 0.001), p-tau (β = 0.183, P < 0.001), and t-tau/Aβ42 (β = 0.094, P = 0.005). Mediation analyses indicated that the relationships of ANU-ADRI scores with cognitive scores were mediated by CSF t-tau or p-tau (mediating proportions ranging from 4.45% to 10.50%). SEM did not reveal that ANU-ADRI scores affected cognition by tau-related pathology and level of CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM2). Conclusion ANU-ADRI scores were associated with cognition and tau pathology. We also revealed a potential pathological mechanism underlying the impact of ANU-ADRI scores on cognition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s13195-024-01427-6 |
| DOI: | 10.1186/s13195-024-01427-6.pdf |
| DOI: | 10.1186/s13195-024-01427-6/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s13195-024-01427-6 https://link.springer.com/content/pdf/10.1186/s13195-024-01427-6.pdf https://link.springer.com/article/10.1186/s13195-024-01427-6/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.B469D3AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13195-024-01427-6 |
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