Academic Journal
The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice
| العنوان: | The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice |
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| المؤلفون: | Varinthra, Peeraporn, Ganesan, Kiruthika, Huang, Shun-Ping, Chompoopong, Supin, Eurtivong, Chatchakorn, Suresh, Pavithra, Wen, Zhi-Hong, Liu, Ingrid Y. |
| المساهمون: | Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Ministry of Science and Technology, Taiwan |
| المصدر: | Frontiers in Aging Neuroscience ; volume 13 ; ISSN 1663-4365 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Alzheimer's disease (AD) is a neurodegenerative disease characterized by an excessive inflammatory response and impaired memory retrieval, including spatial memory, recognition memory, and emotional memory. Acquisition and retrieval of fear memory help one avoid dangers and natural threats. Thus, it is crucial for survival. AD patients with impaired retrieval of fear memory are vulnerable to dangerous conditions. Excessive expression of inflammatory markers is known to impede synaptic transmission and reduce the efficiency of memory retrieval. In wild-type mice, reducing inflammation response can improve fear memory retrieval; however, this effect of this approach is not yet investigated in 3xTg-AD model mice. To date, no satisfactory drug or treatment can attenuate the symptoms of AD despite numerous efforts. In the past few years, the direction of therapeutic drug development for AD has been shifted to natural compounds with anti-inflammatory effect. In the present study, we demonstrate that the compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) is effective in enhancing fear memory retrieval of wild-type and 3xTg-AD mice by reducing the expression of TNF-α, COX-2, and iNOS. We also found that 4-PSB-2 helps increase dendritic spine density, postsynaptic density protein-95 (PSD-95) expression, and long-term potentiation (LTP) in the hippocampus of 3xTg-AD mice. Our study indicates that 4-PSB-2 may be developed as a promising therapeutic compound for treating fear memory impairment of AD patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fnagi.2021.615079 |
| DOI: | 10.3389/fnagi.2021.615079/full |
| الاتاحة: | http://dx.doi.org/10.3389/fnagi.2021.615079 https://www.frontiersin.org/articles/10.3389/fnagi.2021.615079/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.B43B4574 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fnagi.2021.615079 |
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