Academic Journal
Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage
| العنوان: | Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage |
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| المؤلفون: | Li, Dongyu, Liu, Shaojun, Yu, Tingting, Liu, Zhang, Sun, Silin, Bragin, Denis, Shirokov, Alexander, Navolokin, Nikita, Bragina, Olga, Hu, Zhengwu, Kurths, Jürgen, Fedosov, Ivan, Blokhina, Inna, Dubrovski, Alexander, Khorovodov, Alexander, Terskov, Andrey, Tzoy, Maria, Semyachkina-Glushkovskaya, Oxana, Zhu, Dan |
| المساهمون: | National Natural Science Foundation of China, China Postdoctoral Science Foundation, DH | NIHR | Efficacy and Mechanism Evaluation Programme, Russian Science Foundation, Government Council on Grants, Russian Federation |
| المصدر: | Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we show that the meningeal lymphatics is a pathway to remove red blood cells from the brain’s ventricular system of male human, adult and newborn rodents and is a target for non-invasive transcranial near infrared photobiomodulation. Our results uncover the clinical significance of phototherapy of intraventricular hemorrhage in 4-day old male rat pups that have the brain similar to a preterm human brain. The course of phototherapy in newborn rats provides fast recovery after intraventricular hemorrhage due to photo-improvements of lymphatic drainage and clearing functions. These findings shed light on the mechanisms of phototherapy of intraventricular hemorrhage that can be a clinically relevant technology for treatment of neonatal intracerebral bleedings. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-023-41710-y |
| الاتاحة: | http://dx.doi.org/10.1038/s41467-023-41710-y https://www.nature.com/articles/s41467-023-41710-y.pdf https://www.nature.com/articles/s41467-023-41710-y |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.B403D726 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-41710-y |
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