التفاصيل البيبلوغرافية
| العنوان: |
Structure prediction and analysis of Daboia russelii venom through a computational approach |
| المؤلفون: |
John J, Georrge, Urvi.S., Parekh, Mausami, Ashara |
| المساهمون: |
John J, Georrge, Urvi.S., Parekh, Mausami, Ashara |
| بيانات النشر: |
Christ Publications |
| سنة النشر: |
2023 |
| المجموعة: |
Zenodo |
| مصطلحات موضوعية: |
Venom, toxin, poison, docking, Daboia russelii, structure prediction |
| الوصف: |
Numerous animal species naturally produce chemicals to kill or incapacitate prey or defend against predators. Venom is a form of toxin secreted by an animal to cause harm to another. Numerous animal species naturally produce chemical toxins to kill or incapacitate prey or defend against predators. Toxins can be classified according to the location of the body where their effects are most seen. Four different types of venoms will act on our bodies differently. Snake venom is highly modified saliva containing zootoxins which facilitate the immobilisation and digestion of prey and defence against threats. Venoms contain over 20 different compounds, mostly proteins and polypeptides. Daboia russelii is a species of venomous snake in the family Viperidae. Common names are Russell’s Viper and Chain Viper. There is a total of 8 proteins found. Of the 8 proteins, 2 are also present in the human body. Antivenom used for the snakebite is mostly polyvalent snake antivenom. It is given to those who become ill after being bitten by an unidentified snake. It has been found that Russell’s viper venom (RVV) in the presence of lipoid cofactor, clots the plasma of haemophiliacs and proconvertin. RVV is also nephrotoxic in vitro. The analysis and prediction are done by retrieving sequences and predicting 2D and 3D structures by GOR-IV and Swiss Model, respectively. The refinement of structure is also done with the help of various tools. The quality check of structure is also done for a protein based on the Ramachandran plot. There are new perspectives for a better understanding of the venomous function and for fostering the discovery of new venom-derived drug candidates. |
| نوع الوثيقة: |
book part |
| اللغة: |
English |
| Relation: |
https://doi.org/10.5281/zenodo.10696917; https://doi.org/10.5281/zenodo.10696918; oai:zenodo.org:10696918 |
| DOI: |
10.5281/zenodo.10696918 |
| الاتاحة: |
https://doi.org/10.5281/zenodo.10696918 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: |
edsbas.B3EFD318 |
| قاعدة البيانات: |
BASE |