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Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia

التفاصيل البيبلوغرافية
العنوان: Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia
المؤلفون: Mikami, Takashi, Kato, Itaru, Wing, James Badger, Ueno, Hiroo, Tasaka, Keiji, Tanaka, Kuniaki, Kubota, Hirohito, Saida, Satoshi, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Isobe, Tomoya, Hiwatari, Mitsuteru, Okada, Ai, Chiba, Kenichi, Shiraishi, Yuichi, Tanaka, Hiroko, Miyano, Satoru, Arakawa, Yuki, Oshima, Koichi, Koh, Katsuyoshi, Adachi, Souichi, Iwaisako, Keiko, Ogawa, Seishi, Sakaguchi, Shimon, Takita, Junko
المساهمون: 三上, 貴司, 加藤, 格, 上野, 浩生, 田坂, 佳資, 田中, 邦昭, 窪田, 博仁, 才田, 聡, 梅田, 雄嗣, 平松, 英文, 足立, 壯一, 小川, 誠司, 滝田, 順子, 10610454, 70638254, 80397538, 40362503, 00359621
بيانات النشر: Wiley
Japanese Cancer Association
سنة النشر: 2022
المجموعة: Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ
مصطلحات موضوعية: B cell leukemia, immune response, regulatory T cell, relapse, Th1
الوصف: Due to the considerable success of cancer immunotherapy for leukemia, the tumor immune environment has become a focus of intense research; however, there are few reports on the dynamics of the tumor immune environment in leukemia. Here, we analyzed the tumor immune environment in pediatric B cell precursor acute lymphoblastic leukemia by analyzing serial bone marrow samples from nine patients with primary and recurrent disease by mass cytometry using 39 immunophenotype markers, and transcriptome analysis. High-dimensional single-cell mass cytometry analysis elucidated a dynamic shift of T cells from naïve to effector subsets, and clarified that, during relapse, the tumor immune environment comprised a T helper 1-polarized immune profile, together with an increased number of effector regulatory T cells. These results were confirmed in a validation cohort using conventional flow cytometry. Furthermore, RNA transcriptome analysis identified the upregulation of immune-related pathways in B cell precursor acute lymphoblastic leukemia cells during relapse, suggesting interaction with the surrounding environment. In conclusion, a tumor immune environment characterized by a T helper 1-polarized immune profile, with an increased number of effector regulatory T cells, could contribute to the pathophysiology of recurrent B cell precursor acute lymphoblastic leukemia. This information could contribute to the development of effective immunotherapeutic approaches against B cell precursor acute lymphoblastic leukemia relapse.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1347-9032
1349-7006
Relation: http://hdl.handle.net/2433/278421; Cancer Science; 113; 41; 52
الاتاحة: http://hdl.handle.net/2433/278421
Rights: © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. ; This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. ; http://creativecommons.org/licenses/by-nc/4.0/
رقم الانضمام: edsbas.B3A42182
قاعدة البيانات: BASE
الوصف
تدمد:13479032
13497006