Academic Journal
Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
| العنوان: | Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression |
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| المؤلفون: | Costa, Pedro A. C., Silva, Walison N., Prazeres, Pedro H. D. M., Picoli, Caroline C., Guardia, Gabriela D. A., Costa, Alinne C., Oliveira, Mariana A., Guimarães, Pedro P. G., Gonçalves, Ricardo, Pinto, Mauro C. X., Amorim, Jaime H., Azevedo, Vasco A. C., Resende, Rodrigo R., Russo, Remo C., Cunha, Thiago M., Galante, Pedro A. F., Mintz, Akiva, Birbrair, Alexander |
| المساهمون: | Instituto Serrapilheira, National Cancer Institute, American Cancer Society, CNPq |
| المصدر: | Acta Neuropathologica Communications ; volume 9, issue 1 ; ISSN 2051-5960 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by a Designer Drug (DREADD) technology to inhibit or activate sensory neurons’ firing within the melanoma tumor. Melanoma growth and angiogenesis were accelerated following inhibition of sensory neurons’ activity and were reduced following overstimulation of these neurons. Sensory neuron-specific overactivation also induced a boost in the immune surveillance by increasing tumor-infiltrating anti-tumor lymphocytes, while reducing immune-suppressor cells. In humans, a retrospective in silico analysis of melanoma biopsies revealed that increased expression of sensory neurons-related genes within melanoma was associated with improved survival. These findings suggest that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s40478-021-01273-9 |
| DOI: | 10.1186/s40478-021-01273-9.pdf |
| DOI: | 10.1186/s40478-021-01273-9/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s40478-021-01273-9 https://link.springer.com/content/pdf/10.1186/s40478-021-01273-9.pdf https://link.springer.com/article/10.1186/s40478-021-01273-9/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.B380F536 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s40478-021-01273-9 |
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